Inhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy

Inhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy

Antiestrogen therapy (AET) is an alternative to cytotoxic chemotherapy for recurrent ovarian cancer, yet the often short duration of response suggests mechanisms of resistance. We previously demonstrated that tumor microenvironment interleukin-6/leukemia inhibitory factor (IL6/LIF) cytokines induce...

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Bibliographic Details
Main Authors: Lijun Tan, Katelyn Tondo-Steele, Caroline Foster, Carrie McIlwain, Danielle E. Bolland, Howard C. Crawford, Andrew Sciallis, Karen McLean
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
mesenchymal stem cells
ovarian cancer
leukemia inhibitory factor (LIF)
interleukin-6 (IL6)
STAT3
JAK2 inhibition
Online Access:https://www.mdpi.com/2072-6694/14/19/4675

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