Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer
The major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral mucosa by crude fibers, chemical insults by additive slaked lime, and arecoline from areca nut. These would lead to the l...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-12-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221146870 |
| _version_ | 1797974999388127232 |
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| author | Hui-Ching Chuang MD, PhD, FACS Ming-Hsien Tsai MD Yu-Tsai Lin MD, MS, FACS Ming-Huei Chou PhD Kun-Lin Yang MD Chih-Yen Chien MD, FACS |
| author_facet | Hui-Ching Chuang MD, PhD, FACS Ming-Hsien Tsai MD Yu-Tsai Lin MD, MS, FACS Ming-Huei Chou PhD Kun-Lin Yang MD Chih-Yen Chien MD, FACS |
| author_sort | Hui-Ching Chuang MD, PhD, FACS |
| collection | DOAJ |
| description | The major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral mucosa by crude fibers, chemical insults by additive slaked lime, and arecoline from areca nut. These would lead to the local consequence of oral submucosal fibrosis, which is regarded clinically as a precancer lesion and a major cause of trismus. In addition, the components and additives in betel quid contain chemical toxins and carcinogens, which would further affect the oral mucosa and gradually develop a malignancy. Following literature review, aside from having a greater total tumor burden and more local diseases in the oral cavity and digestive tract, patients with betel quid-related oral cancer also have more systemic diseases from metabolic syndrome, hypertension, cardiovascular disease, type II diabetes mellitus, and obesity than those without this habit. In conclusion, those patients who have the history of smoking, alcohol drinking, and betel quid chewing would present much more unique clinical characteristics than those who only have a history of smoking and alcohol drinking. More attention should therefore be paid to pretreatment evaluation, treatment strategy, and posttreatment follow-up among betel quid chewers. |
| first_indexed | 2024-04-11T04:27:33Z |
| format | Article |
| id | doaj.art-d5edca5d416a456f99a112da97ef81a4 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-11T04:27:33Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-d5edca5d416a456f99a112da97ef81a42022-12-29T15:33:27ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-12-012110.1177/15330338221146870Systemic and Local Effects Among Patients With Betel Quid-Related Oral CancerHui-Ching Chuang MD, PhD, FACS0Ming-Hsien Tsai MD1 Yu-Tsai Lin MD, MS, FACS2Ming-Huei Chou PhD3 Kun-Lin Yang MD4Chih-Yen Chien MD, FACS5 Center for mitochondrial Research and Medicine, , Kaohsiung, Taiwan Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung , Taiwan Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung , Taiwan Center for General Education, Cheng-Shiu University, Kaohsiung, Taiwan Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung , Taiwan Institute for Translation Research in Biomedicine, , TaiwanThe major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral mucosa by crude fibers, chemical insults by additive slaked lime, and arecoline from areca nut. These would lead to the local consequence of oral submucosal fibrosis, which is regarded clinically as a precancer lesion and a major cause of trismus. In addition, the components and additives in betel quid contain chemical toxins and carcinogens, which would further affect the oral mucosa and gradually develop a malignancy. Following literature review, aside from having a greater total tumor burden and more local diseases in the oral cavity and digestive tract, patients with betel quid-related oral cancer also have more systemic diseases from metabolic syndrome, hypertension, cardiovascular disease, type II diabetes mellitus, and obesity than those without this habit. In conclusion, those patients who have the history of smoking, alcohol drinking, and betel quid chewing would present much more unique clinical characteristics than those who only have a history of smoking and alcohol drinking. More attention should therefore be paid to pretreatment evaluation, treatment strategy, and posttreatment follow-up among betel quid chewers.https://doi.org/10.1177/15330338221146870 |
| spellingShingle | Hui-Ching Chuang MD, PhD, FACS Ming-Hsien Tsai MD Yu-Tsai Lin MD, MS, FACS Ming-Huei Chou PhD Kun-Lin Yang MD Chih-Yen Chien MD, FACS Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer Technology in Cancer Research & Treatment |
| title | Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer |
| title_full | Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer |
| title_fullStr | Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer |
| title_full_unstemmed | Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer |
| title_short | Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer |
| title_sort | systemic and local effects among patients with betel quid related oral cancer |
| url | https://doi.org/10.1177/15330338221146870 |
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