Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis
Abstract Background Vancomycin-resistant Enterococci (VRE) infections are recurrently reported in different parts of India in the last two decades. However, an up-to-date, countrywide information concerning the prevalence and the rate of VRE in India is limited and hence this study aimed to estimate...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | https://doi.org/10.1186/s13756-023-01287-z |
| _version_ | 1797451433973383168 |
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| author | Emily Smout Navaneethan Palanisamy Sabeel P Valappil |
| author_facet | Emily Smout Navaneethan Palanisamy Sabeel P Valappil |
| author_sort | Emily Smout |
| collection | DOAJ |
| description | Abstract Background Vancomycin-resistant Enterococci (VRE) infections are recurrently reported in different parts of India in the last two decades. However, an up-to-date, countrywide information concerning the prevalence and the rate of VRE in India is limited and hence this study aimed to estimate the pooled prevalence of VRE in India. Methods A literature search was performed using various databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed throughout. Cross-sectional studies reporting the prevalence of VRE in India from human samples whereby at least two Enterococci were isolated between 1 January 2000 and 31 December 2022 were sought for inclusion. Data were extracted and analysed using Microsoft Excel and Comprehensive Meta-analysis version 4, respectively. Results Nineteen studies were included in the analyses. A collective total of 3683 Enterococci isolates were examined, of which 368 were VRE strains. The pooled prevalence of VRE in India was calculated at 12.4% (95% CI: 8.6–17.5; Q = 189.69; I 2 = 90.51%; p = < 0.001). E. faecalis was the most frequently isolated species (1450 [39.37%]) followed by E. faecium (724 [19.66%]). Amongst the VRE strains, E. faecium was the most prevalent (214 [58.15%]) followed by E. faecalis (134 [36.41%]). An upsurge in the rate of VRE infections was observed in India over time: VRE prevalence was estimated at 4.8% between 2000 and 2010 and 14.1% between 2011 and 2020. Conclusion This study presents the most up-to-date information on the rate of VRE infections in India. Though lower than the findings for some less developed countries, VRE prevalence in India is notable and on the rise. |
| first_indexed | 2024-03-09T14:54:36Z |
| format | Article |
| id | doaj.art-d5edd30d33fa49769320690ad83489fe |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-03-09T14:54:36Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-d5edd30d33fa49769320690ad83489fe2023-11-26T14:16:36ZengBMCAntimicrobial Resistance and Infection Control2047-29942023-08-0112111310.1186/s13756-023-01287-zPrevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysisEmily Smout0Navaneethan Palanisamy1Sabeel P Valappil2Chester Medical School, University of ChesterChester Medical School, University of ChesterChester Medical School, University of ChesterAbstract Background Vancomycin-resistant Enterococci (VRE) infections are recurrently reported in different parts of India in the last two decades. However, an up-to-date, countrywide information concerning the prevalence and the rate of VRE in India is limited and hence this study aimed to estimate the pooled prevalence of VRE in India. Methods A literature search was performed using various databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed throughout. Cross-sectional studies reporting the prevalence of VRE in India from human samples whereby at least two Enterococci were isolated between 1 January 2000 and 31 December 2022 were sought for inclusion. Data were extracted and analysed using Microsoft Excel and Comprehensive Meta-analysis version 4, respectively. Results Nineteen studies were included in the analyses. A collective total of 3683 Enterococci isolates were examined, of which 368 were VRE strains. The pooled prevalence of VRE in India was calculated at 12.4% (95% CI: 8.6–17.5; Q = 189.69; I 2 = 90.51%; p = < 0.001). E. faecalis was the most frequently isolated species (1450 [39.37%]) followed by E. faecium (724 [19.66%]). Amongst the VRE strains, E. faecium was the most prevalent (214 [58.15%]) followed by E. faecalis (134 [36.41%]). An upsurge in the rate of VRE infections was observed in India over time: VRE prevalence was estimated at 4.8% between 2000 and 2010 and 14.1% between 2011 and 2020. Conclusion This study presents the most up-to-date information on the rate of VRE infections in India. Though lower than the findings for some less developed countries, VRE prevalence in India is notable and on the rise.https://doi.org/10.1186/s13756-023-01287-zVancomycinVancomycin-resistant EnterococciAntimicrobial resistancePrevalence |
| spellingShingle | Emily Smout Navaneethan Palanisamy Sabeel P Valappil Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis Antimicrobial Resistance and Infection Control Vancomycin Vancomycin-resistant Enterococci Antimicrobial resistance Prevalence |
| title | Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis |
| title_full | Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis |
| title_fullStr | Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis |
| title_short | Prevalence of vancomycin-resistant Enterococci in India between 2000 and 2022: a systematic review and meta-analysis |
| title_sort | prevalence of vancomycin resistant enterococci in india between 2000 and 2022 a systematic review and meta analysis |
| topic | Vancomycin Vancomycin-resistant Enterococci Antimicrobial resistance Prevalence |
| url | https://doi.org/10.1186/s13756-023-01287-z |
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