The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China
ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with an increasing annual incidence rate. In this case report, we presented two patients infected with the SFTS virus, suggesting a potential direct transmission route from camels to humans through blood con...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2309990 |
| _version_ | 1797317017563299840 |
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| author | Yulan Sun Daitao Zhang Hui Liu Chunlai Ruan Xiangfeng Dou Zhenyong Ren Ziruo Ge Zhizhong Du Haoyuan Jin Dan Li Hui Xue Wei Liu Zhihai Chen Quanyi Wang |
| author_facet | Yulan Sun Daitao Zhang Hui Liu Chunlai Ruan Xiangfeng Dou Zhenyong Ren Ziruo Ge Zhizhong Du Haoyuan Jin Dan Li Hui Xue Wei Liu Zhihai Chen Quanyi Wang |
| author_sort | Yulan Sun |
| collection | DOAJ |
| description | ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with an increasing annual incidence rate. In this case report, we presented two patients infected with the SFTS virus, suggesting a potential direct transmission route from camels to humans through blood contact. Both patients developed symptoms after engaging in the slaughtering of one sick camel, while their family members living in the same environment or co-diners remained unaffected. Subsequent detection revealed a high viral load of SFTS virus, reaching 1010 viral RNA copies/ml, in the sample obtained from the sick camel. Metagenomic sequencing did not identify any other pathogens. The SFTS virus was successfully isolated from both patient and camel samples. The complete nucleotide sequences obtained from the infected patients demonstrated a remarkable 100% similarity to those found in the camel, and genetic evolution analysis classified the virus as genotype A. Additionally, partial sequences of the SFTS virus were identified in ticks captured from the camel rearing environment, however, these sequences showed only 95.9% similarity to those found in camel and humans. Furthermore, immunoglobulin M and immunoglobulin G antibodies were detected in serum samples collected from the patient. Our findings provide evidence that camel may serve as a competent reservoir for transmitting the SFTS virus to humans. Further in vitro investigations into SFTS virus infections in large animals are warranted to understand their role in viral maintenance and transmission. |
| first_indexed | 2024-03-08T03:26:50Z |
| format | Article |
| id | doaj.art-d5f37ebc86304994b6432d05b0e02118 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T03:26:50Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-d5f37ebc86304994b6432d05b0e021182024-02-11T19:24:39ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2309990The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in ChinaYulan Sun0Daitao Zhang1Hui Liu2Chunlai Ruan3Xiangfeng Dou4Zhenyong Ren5Ziruo Ge6Zhizhong Du7Haoyuan Jin8Dan Li9Hui Xue10Wei Liu11Zhihai Chen12Quanyi Wang13Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaBeijing Pinggu District Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaBeijing Pinggu District Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaBeijing Pinggu District Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with an increasing annual incidence rate. In this case report, we presented two patients infected with the SFTS virus, suggesting a potential direct transmission route from camels to humans through blood contact. Both patients developed symptoms after engaging in the slaughtering of one sick camel, while their family members living in the same environment or co-diners remained unaffected. Subsequent detection revealed a high viral load of SFTS virus, reaching 1010 viral RNA copies/ml, in the sample obtained from the sick camel. Metagenomic sequencing did not identify any other pathogens. The SFTS virus was successfully isolated from both patient and camel samples. The complete nucleotide sequences obtained from the infected patients demonstrated a remarkable 100% similarity to those found in the camel, and genetic evolution analysis classified the virus as genotype A. Additionally, partial sequences of the SFTS virus were identified in ticks captured from the camel rearing environment, however, these sequences showed only 95.9% similarity to those found in camel and humans. Furthermore, immunoglobulin M and immunoglobulin G antibodies were detected in serum samples collected from the patient. Our findings provide evidence that camel may serve as a competent reservoir for transmitting the SFTS virus to humans. Further in vitro investigations into SFTS virus infections in large animals are warranted to understand their role in viral maintenance and transmission.https://www.tandfonline.com/doi/10.1080/22221751.2024.2309990Severe fever with thrombocytopenia syndromecamel to humanstickgenotype AChina |
| spellingShingle | Yulan Sun Daitao Zhang Hui Liu Chunlai Ruan Xiangfeng Dou Zhenyong Ren Ziruo Ge Zhizhong Du Haoyuan Jin Dan Li Hui Xue Wei Liu Zhihai Chen Quanyi Wang The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China Emerging Microbes and Infections Severe fever with thrombocytopenia syndrome camel to humans tick genotype A China |
| title | The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China |
| title_full | The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China |
| title_fullStr | The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China |
| title_full_unstemmed | The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China |
| title_short | The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China |
| title_sort | first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in china |
| topic | Severe fever with thrombocytopenia syndrome camel to humans tick genotype A China |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2309990 |
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