Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review
Abstract Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) is a highly infectious disease and worldwide health problem. Based on the WHO TB report, 9 million active TB cases are emerging, leading to 2 million deaths each year. The recent emergence of multidrug-resistant tuberc...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07944-9 |
| _version_ | 1797977613496483840 |
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| author | Fatemeh Zeynali kelishomi Susan Khanjani Fatemeh Fardsanei Hediyeh Saghi Sarabi Farhad Nikkhahi Behzad Dehghani |
| author_facet | Fatemeh Zeynali kelishomi Susan Khanjani Fatemeh Fardsanei Hediyeh Saghi Sarabi Farhad Nikkhahi Behzad Dehghani |
| author_sort | Fatemeh Zeynali kelishomi |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) is a highly infectious disease and worldwide health problem. Based on the WHO TB report, 9 million active TB cases are emerging, leading to 2 million deaths each year. The recent emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) strains emphasizes the necessity to improve novel therapeutic plans. Among the various developing antibacterial approaches, phage therapy is thought to be a precise hopeful resolution. Mycobacteriophages are viruses that infect bacteria such as Mycobacterium spp., containing the M. tuberculosis complex. Phages and phage-derived proteins can act as promising antimicrobial agents. Also, phage cocktails can broaden the spectrum of lysis activity against bacteria. Recent researches have also shown the effective combination of antibiotics and phages to defeat the infective bacteria. There are limitations and concerns about phage therapy. For example, human immune response to phage therapy, transferring antibiotic resistance genes, emerging resistance to phages, and safety issues. So, in the present study, we introduced mycobacteriophages, their use as therapeutic agents, and their advantages and limitations as therapeutic applications. |
| first_indexed | 2024-04-11T05:10:08Z |
| format | Article |
| id | doaj.art-d5f4e3a621164643b5abdf00d2316a46 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-11T05:10:08Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-d5f4e3a621164643b5abdf00d2316a462022-12-25T12:06:27ZengBMCBMC Infectious Diseases1471-23342022-12-0122111410.1186/s12879-022-07944-9Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a reviewFatemeh Zeynali kelishomi0Susan Khanjani1Fatemeh Fardsanei2Hediyeh Saghi Sarabi3Farhad Nikkhahi4Behzad Dehghani5Medical Microbiology Research Center, Qazvin University of Medical SciencesMedical Microbiology Research Center, Qazvin University of Medical SciencesMedical Microbiology Research Center, Qazvin University of Medical SciencesMedical Microbiology Research Center, Qazvin University of Medical SciencesMedical Microbiology Research Center, Qazvin University of Medical SciencesDepartment of Bacteriology-Virology, Shiraz University of Medical SciencesAbstract Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) is a highly infectious disease and worldwide health problem. Based on the WHO TB report, 9 million active TB cases are emerging, leading to 2 million deaths each year. The recent emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) strains emphasizes the necessity to improve novel therapeutic plans. Among the various developing antibacterial approaches, phage therapy is thought to be a precise hopeful resolution. Mycobacteriophages are viruses that infect bacteria such as Mycobacterium spp., containing the M. tuberculosis complex. Phages and phage-derived proteins can act as promising antimicrobial agents. Also, phage cocktails can broaden the spectrum of lysis activity against bacteria. Recent researches have also shown the effective combination of antibiotics and phages to defeat the infective bacteria. There are limitations and concerns about phage therapy. For example, human immune response to phage therapy, transferring antibiotic resistance genes, emerging resistance to phages, and safety issues. So, in the present study, we introduced mycobacteriophages, their use as therapeutic agents, and their advantages and limitations as therapeutic applications.https://doi.org/10.1186/s12879-022-07944-9Mycobacterium tuberculosisDrug resistanceMycobacteriophagesPhage therapy |
| spellingShingle | Fatemeh Zeynali kelishomi Susan Khanjani Fatemeh Fardsanei Hediyeh Saghi Sarabi Farhad Nikkhahi Behzad Dehghani Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review BMC Infectious Diseases Mycobacterium tuberculosis Drug resistance Mycobacteriophages Phage therapy |
| title | Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review |
| title_full | Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review |
| title_fullStr | Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review |
| title_full_unstemmed | Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review |
| title_short | Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review |
| title_sort | bacteriophages of mycobacterium tuberculosis their diversity and potential therapeutic uses a review |
| topic | Mycobacterium tuberculosis Drug resistance Mycobacteriophages Phage therapy |
| url | https://doi.org/10.1186/s12879-022-07944-9 |
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