An Iron Transporter Is Involved in Iron Homeostasis, Energy Metabolism, Oxidative Stress, and Metacyclogenesis in Trypanosoma cruzi

An Iron Transporter Is Involved in Iron Homeostasis, Energy Metabolism, Oxidative Stress, and Metacyclogenesis in Trypanosoma cruzi

The parasite Trypanosoma cruzi causes Chagas’ disease; both heme and ionic Fe are required for its optimal growth, differentiation, and invasion. Fe is an essential cofactor in many metabolic pathways. Fe is also harmful due to catalyzing the formation of reactive O2 species; for this reason, all li...

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Bibliographic Details
Main Authors: Claudia F. Dick, Nathália Rocco-Machado, André L. A. Dos-Santos, Luiz F. Carvalho-Kelly, Carolina L. Alcantara, Narcisa L. Cunha-E-Silva, José R. Meyer-Fernandes, Adalberto Vieyra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
iron transporter
Trypanosoma cruzi
reactive O2 species production
parasite O2 consumption
parasite proliferation
parasite differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.789401/full

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