The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children
Physical activity (PA) can improve children’s executive functioning (EF), which might be caused by increased levels of brain-derived neurotrophic factor (BDNF). This study investigated whether acute and/or chronic PA leads to increased BDNF levels and enhanced EF in children. <b>Methods:</b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/5/596 |
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| author | Julie Latomme Patrick Calders Hilde Van Waelvelde Tineke Mariën Marieke De Craemer |
| author_facet | Julie Latomme Patrick Calders Hilde Van Waelvelde Tineke Mariën Marieke De Craemer |
| author_sort | Julie Latomme |
| collection | DOAJ |
| description | Physical activity (PA) can improve children’s executive functioning (EF), which might be caused by increased levels of brain-derived neurotrophic factor (BDNF). This study investigated whether acute and/or chronic PA leads to increased BDNF levels and enhanced EF in children. <b>Methods:</b> In total, 47 children (mean age 9.69 ± 0.60; 46.8% boys) participated. Children performed a maximal exercise test to measure acute PA. Before and after, BDNF was collected and EF was measured. Chronic PA was proxy-reported. Repeated Measures ANOVAs were performed to study the effect of acute PA on BDNF and EF. Mediation analyses were performed to investigate the mediation effect of BDNF on the association between chronic PA and BDNF. <b>Results:</b> A borderline significant effect of acute PA on BDNF was found (F = 3.32, <i>p</i> = 0.075) with an increase in BDNF (+29.58 pg/mL) after acute PA. A significant effect was found for performance on inhibition tasks (Flanker (accuracy +5.67%, <i>p</i> = 0.034) and Go/No-Go (+0.15%, <i>p</i> = 0.022)). No effect of acute PA was found on the EF outcomes. No significant correlation between chronic PA and EFs nor BDNF was found. <b>Conclusions:</b> Acute PA might increase BDNF and improve some EFs (i.e., inhibition) in children. Chronic PA was not associated with EF nor BDNF. <b>Trial Registration Number:</b> NCT02503579. |
| first_indexed | 2024-03-10T03:10:05Z |
| format | Article |
| id | doaj.art-d5f7d54c137c4cc193b0eff26e82aa16 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T03:10:05Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-d5f7d54c137c4cc193b0eff26e82aa162023-11-23T10:29:35ZengMDPI AGChildren2227-90672022-04-019559610.3390/children9050596The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in ChildrenJulie Latomme0Patrick Calders1Hilde Van Waelvelde2Tineke Mariën3Marieke De Craemer4Department of Movement and Sports Sciences, Ghent University, 9000 Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, BelgiumPhysical activity (PA) can improve children’s executive functioning (EF), which might be caused by increased levels of brain-derived neurotrophic factor (BDNF). This study investigated whether acute and/or chronic PA leads to increased BDNF levels and enhanced EF in children. <b>Methods:</b> In total, 47 children (mean age 9.69 ± 0.60; 46.8% boys) participated. Children performed a maximal exercise test to measure acute PA. Before and after, BDNF was collected and EF was measured. Chronic PA was proxy-reported. Repeated Measures ANOVAs were performed to study the effect of acute PA on BDNF and EF. Mediation analyses were performed to investigate the mediation effect of BDNF on the association between chronic PA and BDNF. <b>Results:</b> A borderline significant effect of acute PA on BDNF was found (F = 3.32, <i>p</i> = 0.075) with an increase in BDNF (+29.58 pg/mL) after acute PA. A significant effect was found for performance on inhibition tasks (Flanker (accuracy +5.67%, <i>p</i> = 0.034) and Go/No-Go (+0.15%, <i>p</i> = 0.022)). No effect of acute PA was found on the EF outcomes. No significant correlation between chronic PA and EFs nor BDNF was found. <b>Conclusions:</b> Acute PA might increase BDNF and improve some EFs (i.e., inhibition) in children. Chronic PA was not associated with EF nor BDNF. <b>Trial Registration Number:</b> NCT02503579.https://www.mdpi.com/2227-9067/9/5/596physical activityexercisebrain-derived neurotrophic factorexecutive functioningchildren |
| spellingShingle | Julie Latomme Patrick Calders Hilde Van Waelvelde Tineke Mariën Marieke De Craemer The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children Children physical activity exercise brain-derived neurotrophic factor executive functioning children |
| title | The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children |
| title_full | The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children |
| title_fullStr | The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children |
| title_full_unstemmed | The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children |
| title_short | The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children |
| title_sort | role of brain derived neurotrophic factor bdnf in the relation between physical activity and executive functioning in children |
| topic | physical activity exercise brain-derived neurotrophic factor executive functioning children |
| url | https://www.mdpi.com/2227-9067/9/5/596 |
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