Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study
ObjectivesThis study aimed to identify the potential risk factors for small airway dysfunction (SAD) in non-smokers with chronic cough.MethodsNon-smokers with chronic cough who underwent lung function tests at Xiangya Hospital from May 2019 to May 2020 were enrolled, and divided into the derivation...
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Frontiers Media S.A.
2022-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.912100/full |
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| author | Bingrong Zhao Bingrong Zhao Bingrong Zhao Bingrong Zhao Bingrong Zhao Lu Bai Lu Bai Lu Bai Lu Bai Lu Bai Rongjun Wan Rongjun Wan Rongjun Wan Rongjun Wan Rongjun Wan Yanan Wang Yanan Wang Yanan Wang Yanan Wang Yanan Wang Ling Qin Ling Qin Ling Qin Ling Qin Ling Qin Qiming Xiao Qiming Xiao Qiming Xiao Qiming Xiao Qiming Xiao Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Chengping Hu Chengping Hu Chengping Hu Chengping Hu Chengping Hu Juan Jiang Juan Jiang Juan Jiang Juan Jiang Juan Jiang |
| author_facet | Bingrong Zhao Bingrong Zhao Bingrong Zhao Bingrong Zhao Bingrong Zhao Lu Bai Lu Bai Lu Bai Lu Bai Lu Bai Rongjun Wan Rongjun Wan Rongjun Wan Rongjun Wan Rongjun Wan Yanan Wang Yanan Wang Yanan Wang Yanan Wang Yanan Wang Ling Qin Ling Qin Ling Qin Ling Qin Ling Qin Qiming Xiao Qiming Xiao Qiming Xiao Qiming Xiao Qiming Xiao Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Chengping Hu Chengping Hu Chengping Hu Chengping Hu Chengping Hu Juan Jiang Juan Jiang Juan Jiang Juan Jiang Juan Jiang |
| author_sort | Bingrong Zhao |
| collection | DOAJ |
| description | ObjectivesThis study aimed to identify the potential risk factors for small airway dysfunction (SAD) in non-smokers with chronic cough.MethodsNon-smokers with chronic cough who underwent lung function tests at Xiangya Hospital from May 2019 to May 2020 were enrolled, and divided into the derivation and validation cohorts based on their hospital admission time. SAD was determined based on the presence of at least two of the following three indicators of lung function being less than 65% of predicted: maximal mid-expiratory flow, forced expiratory flow at 50% of forced vital capacity (FVC), and forced expiratory flow at 75% of FVC. Clinical data of these patients were collected. Risk factors for SAD were identified by logistic regression analysis in the derivation cohort and further confirmed in the validation cohort.ResultsIn total, 316 patients (152 in the non-SAD group and 164 in the SAD group) were included in the derivation cohort. Compared with the non-SAD group, the SAD group had a higher proportion of female patients (82.3 vs. 59.2%, P < 0.001), was more commonly exposed to second-hand smoke (SHS) (61.6 vs. 27.6%, P < 0.001), and tended to be older (median age, 45.5 vs. 40.0 years old, P = 0.004). The median FVC, forced expiratory volume in one second (FEV1) % pred, FEV1/FVC ratio, and peak expiratory flow (PEF) % pred were slightly lower in the SAD group. Multivariable logistic analysis showed that exposure to SHS was an independent risk factor (OR 4.166 [95% CI 2.090–8.302], P < 0.001) for SAD in non-smokers with chronic cough after adjusting for related variables. In the validation cohort (n = 146), patients with SHS exposure had a relative risk of 1.976 (95% CI 1.246–3.135, P = 0.004) for SAD compared to those without SHS exposure. Multivariable logistic analysis consistently confirmed that exposure to SHS was an independent risk factor (OR 3.041 [95% CI 1.458–6.344], P = 0.003) for SAD in non-smokers.ConclusionsExposure to SHS is independently associated with a higher risk of SAD in non-smokers with chronic cough. Reduction in SHS exposure may ameliorate lung function, thus lowering the risk of irreversible airway obstruction. |
| first_indexed | 2024-12-12T01:07:05Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-12T01:07:05Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-d5f809cd6d724862a63a5dc66a36b8322022-12-22T00:43:34ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-07-011010.3389/fpubh.2022.912100912100Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control studyBingrong Zhao0Bingrong Zhao1Bingrong Zhao2Bingrong Zhao3Bingrong Zhao4Lu Bai5Lu Bai6Lu Bai7Lu Bai8Lu Bai9Rongjun Wan10Rongjun Wan11Rongjun Wan12Rongjun Wan13Rongjun Wan14Yanan Wang15Yanan Wang16Yanan Wang17Yanan Wang18Yanan Wang19Ling Qin20Ling Qin21Ling Qin22Ling Qin23Ling Qin24Qiming Xiao25Qiming Xiao26Qiming Xiao27Qiming Xiao28Qiming Xiao29Pinhua Pan30Pinhua Pan31Pinhua Pan32Pinhua Pan33Pinhua Pan34Chengping Hu35Chengping Hu36Chengping Hu37Chengping Hu38Chengping Hu39Juan Jiang40Juan Jiang41Juan Jiang42Juan Jiang43Juan Jiang44Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaObjectivesThis study aimed to identify the potential risk factors for small airway dysfunction (SAD) in non-smokers with chronic cough.MethodsNon-smokers with chronic cough who underwent lung function tests at Xiangya Hospital from May 2019 to May 2020 were enrolled, and divided into the derivation and validation cohorts based on their hospital admission time. SAD was determined based on the presence of at least two of the following three indicators of lung function being less than 65% of predicted: maximal mid-expiratory flow, forced expiratory flow at 50% of forced vital capacity (FVC), and forced expiratory flow at 75% of FVC. Clinical data of these patients were collected. Risk factors for SAD were identified by logistic regression analysis in the derivation cohort and further confirmed in the validation cohort.ResultsIn total, 316 patients (152 in the non-SAD group and 164 in the SAD group) were included in the derivation cohort. Compared with the non-SAD group, the SAD group had a higher proportion of female patients (82.3 vs. 59.2%, P < 0.001), was more commonly exposed to second-hand smoke (SHS) (61.6 vs. 27.6%, P < 0.001), and tended to be older (median age, 45.5 vs. 40.0 years old, P = 0.004). The median FVC, forced expiratory volume in one second (FEV1) % pred, FEV1/FVC ratio, and peak expiratory flow (PEF) % pred were slightly lower in the SAD group. Multivariable logistic analysis showed that exposure to SHS was an independent risk factor (OR 4.166 [95% CI 2.090–8.302], P < 0.001) for SAD in non-smokers with chronic cough after adjusting for related variables. In the validation cohort (n = 146), patients with SHS exposure had a relative risk of 1.976 (95% CI 1.246–3.135, P = 0.004) for SAD compared to those without SHS exposure. Multivariable logistic analysis consistently confirmed that exposure to SHS was an independent risk factor (OR 3.041 [95% CI 1.458–6.344], P = 0.003) for SAD in non-smokers.ConclusionsExposure to SHS is independently associated with a higher risk of SAD in non-smokers with chronic cough. Reduction in SHS exposure may ameliorate lung function, thus lowering the risk of irreversible airway obstruction.https://www.frontiersin.org/articles/10.3389/fpubh.2022.912100/fullsmall airway dysfunctionsecond-hand smokechronic coughnon-smokergenderenvironmental tobacco smoke |
| spellingShingle | Bingrong Zhao Bingrong Zhao Bingrong Zhao Bingrong Zhao Bingrong Zhao Lu Bai Lu Bai Lu Bai Lu Bai Lu Bai Rongjun Wan Rongjun Wan Rongjun Wan Rongjun Wan Rongjun Wan Yanan Wang Yanan Wang Yanan Wang Yanan Wang Yanan Wang Ling Qin Ling Qin Ling Qin Ling Qin Ling Qin Qiming Xiao Qiming Xiao Qiming Xiao Qiming Xiao Qiming Xiao Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Chengping Hu Chengping Hu Chengping Hu Chengping Hu Chengping Hu Juan Jiang Juan Jiang Juan Jiang Juan Jiang Juan Jiang Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study Frontiers in Public Health small airway dysfunction second-hand smoke chronic cough non-smoker gender environmental tobacco smoke |
| title | Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study |
| title_full | Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study |
| title_fullStr | Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study |
| title_full_unstemmed | Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study |
| title_short | Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study |
| title_sort | exposure to second hand smoke is an independent risk factor of small airway dysfunction in non smokers with chronic cough a retrospective case control study |
| topic | small airway dysfunction second-hand smoke chronic cough non-smoker gender environmental tobacco smoke |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.912100/full |
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