An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in <i>Drosophila melanogaster</i>

An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in <i>Drosophila melanogaster</i>

Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor symptoms and dopaminergic cell loss. A pre-symptomatic phase characterized by non-motor symptoms precedes the onset of motor alterations. Two recent PET studies in human carriers of mutations associated with familial PD d...

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Bibliographic Details
Main Authors: Rafaella V. Zárate, Sergio Hidalgo, Nicole Navarro, Daniela Molina-Mateo, Duxan Arancibia, Francisca Rojo-Cortés, Carlos Oliva, María Estela Andrés, Pedro Zamorano, Jorge M. Campusano
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
Parkinson’s disease
<i>Drosophila melanogaster</i>
PINK1
pre-symptomatic phase
serotonin
SERT
Online Access:https://www.mdpi.com/2073-4409/11/9/1544

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