Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems
Propolis is a natural product with a plethora of biological effects, utilized by traditional medicine since antiquity. However, its application as a pharmaceutical is hindered by its variable composition and difficult standardization. CAPE has been shown to be a major component of propolis, with a l...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2019-12-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/38571/download/pdf/ |
| _version_ | 1811331425327120384 |
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| author | Yordan Yordanov |
| author_facet | Yordan Yordanov |
| author_sort | Yordan Yordanov |
| collection | DOAJ |
| description | Propolis is a natural product with a plethora of biological effects, utilized by traditional medicine since antiquity. However, its application as a pharmaceutical is hindered by its variable composition and difficult standardization. CAPE has been shown to be a major component of propolis, with a large contribution to its pharmacological effects, among which the anti-inflammatory, antioxidant and antineoplastic have been attracting most attention. The current review article aims to present the cornerstone pharmacological studies of CAPE throughout the years, following its discovery, which confirmed its primary importance among propolis constituents and opened the path to its intensive research as a potential pharmaceutical. We present the diversity of drug delivery systems of CAPE, which have been developed to improve its efficacy in in vitro and in vivo disease models and discuss their primary promises and weaknesses. The increased interest in recent years over more practical approaches of CAPE research such as its pharmaceutical formulation comes to show that it has a potential to become commercialized as a pharmaceutical. |
| first_indexed | 2024-04-13T16:19:22Z |
| format | Article |
| id | doaj.art-d5fc52af56a84758a50f85d2800243f9 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-04-13T16:19:22Z |
| publishDate | 2019-12-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-d5fc52af56a84758a50f85d2800243f92022-12-22T02:39:58ZengPensoft PublishersPharmacia2603-557X2019-12-0166422323110.3897/pharmacia.66.e3857138571Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systemsYordan Yordanov0Medical University of SofiaPropolis is a natural product with a plethora of biological effects, utilized by traditional medicine since antiquity. However, its application as a pharmaceutical is hindered by its variable composition and difficult standardization. CAPE has been shown to be a major component of propolis, with a large contribution to its pharmacological effects, among which the anti-inflammatory, antioxidant and antineoplastic have been attracting most attention. The current review article aims to present the cornerstone pharmacological studies of CAPE throughout the years, following its discovery, which confirmed its primary importance among propolis constituents and opened the path to its intensive research as a potential pharmaceutical. We present the diversity of drug delivery systems of CAPE, which have been developed to improve its efficacy in in vitro and in vivo disease models and discuss their primary promises and weaknesses. The increased interest in recent years over more practical approaches of CAPE research such as its pharmaceutical formulation comes to show that it has a potential to become commercialized as a pharmaceutical.https://pharmacia.pensoft.net/article/38571/download/pdf/ |
| spellingShingle | Yordan Yordanov Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems Pharmacia |
| title | Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems |
| title_full | Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems |
| title_fullStr | Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems |
| title_full_unstemmed | Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems |
| title_short | Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems |
| title_sort | caffeic acid phenethyl ester cape cornerstone pharmacological studies and drug delivery systems |
| url | https://pharmacia.pensoft.net/article/38571/download/pdf/ |
| work_keys_str_mv | AT yordanyordanov caffeicacidphenethylestercapecornerstonepharmacologicalstudiesanddrugdeliverysystems |