Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

The locus coeruleus (LC) projects throughout the brain and spinal cord and is the major source of central noradrenaline. It remains unclear whether the LC acts functionally as a single global effector or as discrete modules. Specifically, while spinal-projections from LC neurons can exert analgesic...

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Bibliographic Details
Main Authors: Stefan Hirschberg, Yong Li, Andrew Randall, Eric J Kremer, Anthony E Pickering
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
noradrenaline
locus coeruleus
pain
endogenous analgesia
chemogenetics
attention
Online Access:https://elifesciences.org/articles/29808

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