Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study
IntroductionFour years after the onset of the COVID-19 pandemic, the frequency of long-term post-COVID-19 cognitive symptoms is a matter of concern given the impact it may have on the work and quality of life of affected people.ObjectiveTo evaluate the incidence of post-acute COVID-19 cognitive symp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1282067/full |
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| author | Lívia Paula Freire Bonfim Thais Rotsen Correa Bruno Cabaleiro Cortizo Freire Thais Marques Pedroso Thais Marques Pedroso Daniella Nunes Pereira Thalita Baptisteli Fernandes Luciane Kopittke Clara Rodrigues Alves de Oliveira Clara Rodrigues Alves de Oliveira Antonio Lucio Teixeira Antonio Lucio Teixeira Milena Soriano Marcolino Milena Soriano Marcolino Milena Soriano Marcolino |
| author_facet | Lívia Paula Freire Bonfim Thais Rotsen Correa Bruno Cabaleiro Cortizo Freire Thais Marques Pedroso Thais Marques Pedroso Daniella Nunes Pereira Thalita Baptisteli Fernandes Luciane Kopittke Clara Rodrigues Alves de Oliveira Clara Rodrigues Alves de Oliveira Antonio Lucio Teixeira Antonio Lucio Teixeira Milena Soriano Marcolino Milena Soriano Marcolino Milena Soriano Marcolino |
| author_sort | Lívia Paula Freire Bonfim |
| collection | DOAJ |
| description | IntroductionFour years after the onset of the COVID-19 pandemic, the frequency of long-term post-COVID-19 cognitive symptoms is a matter of concern given the impact it may have on the work and quality of life of affected people.ObjectiveTo evaluate the incidence of post-acute COVID-19 cognitive symptoms, as well as the associated risk factors.MethodsRetrospective cohort, including outpatients with laboratory-confirmed COVID-19 and who were assisted by a public telehealth service provided by the Telehealth Network of Minas Gerais (TNMG), during the acute phase of the disease, between December/2020 and March/2022. Data were collected through a structured questionnaire, applied via phone calls, regarding the persistence of COVID-19 symptoms after 12 weeks of the disease. Cognitive symptoms were defined as any of the following: memory loss, problems concentrating, word finding difficulties, and difficulty thinking clearly.ResultsFrom 630 patients who responded to the questionnaire, 23.7% presented cognitive symptoms at 12 weeks after infection. These patients had a higher median age (33 [IQR 25–46] vs. 30 [IQR 24–42] years-old, p = 0.042) with a higher prevalence in the female sex (80.5% vs. 62.2%, p < 0.001) when compared to those who did not present cognitive symptoms, as well as a lower prevalence of smoking (8.7% vs. 16.2%, p = 0.024). Furthermore, patients with persistent cognitive symptoms were more likely to have been infected during the second wave of COVID-19 rather than the third (31.0% vs. 21.3%, p = 0.014). Patients who needed to seek in-person care during the acute phase of the disease were more likely to report post-acute cognitive symptoms (21.5% vs. 9.3%, p < 0,001). In multivariate logistic regression analysis, cognitive symptoms were associated with female sex (OR 2.24, CI 95% 1.41–3.57), fatigue (OR 2.33, CI 95% 1.19–4.56), depression (OR 5.37, CI 95% 2.19–13.15) and the need for seek in-person care during acute COVID-19 (OR 2.23, CI 95% 1.30–3.81).ConclusionIn this retrospective cohort of patients with mostly mild COVID-19, cognitive symptoms were present in 23.7% of patients with COVID-19 at 12 weeks after infection. Female sex, fatigue, depression and the need to seek in-person care during acute COVID-19 were the risk factors independently associated with this condition. |
| first_indexed | 2024-04-24T08:44:45Z |
| format | Article |
| id | doaj.art-d5fe7e7b5e994315b68a8096cc5ac7d9 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T08:44:45Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-d5fe7e7b5e994315b68a8096cc5ac7d92024-04-16T14:16:50ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-04-011210.3389/fpubh.2024.12820671282067Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort studyLívia Paula Freire Bonfim0Thais Rotsen Correa1Bruno Cabaleiro Cortizo Freire2Thais Marques Pedroso3Thais Marques Pedroso4Daniella Nunes Pereira5Thalita Baptisteli Fernandes6Luciane Kopittke7Clara Rodrigues Alves de Oliveira8Clara Rodrigues Alves de Oliveira9Antonio Lucio Teixeira10Antonio Lucio Teixeira11Milena Soriano Marcolino12Milena Soriano Marcolino13Milena Soriano Marcolino14Tropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilStatistics Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTelehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilFaculdade de Ciências Médicas de Minas Gerais (FCMMG), Belo Horizonte, Minas Gerais, BrazilHospital Nossa Senhora da Conceição, Porto Alegre, Rio Grande do Sul, BrazilTropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTelehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilNeuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, UT Health Houston, Houston, TX, United StatesTropical Medicine and Infectious Disease Program, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilTelehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilNational Institute for Health Technology Assessment (IATS), Porto Alegre, Rio Grande do Sul, BrazilIntroductionFour years after the onset of the COVID-19 pandemic, the frequency of long-term post-COVID-19 cognitive symptoms is a matter of concern given the impact it may have on the work and quality of life of affected people.ObjectiveTo evaluate the incidence of post-acute COVID-19 cognitive symptoms, as well as the associated risk factors.MethodsRetrospective cohort, including outpatients with laboratory-confirmed COVID-19 and who were assisted by a public telehealth service provided by the Telehealth Network of Minas Gerais (TNMG), during the acute phase of the disease, between December/2020 and March/2022. Data were collected through a structured questionnaire, applied via phone calls, regarding the persistence of COVID-19 symptoms after 12 weeks of the disease. Cognitive symptoms were defined as any of the following: memory loss, problems concentrating, word finding difficulties, and difficulty thinking clearly.ResultsFrom 630 patients who responded to the questionnaire, 23.7% presented cognitive symptoms at 12 weeks after infection. These patients had a higher median age (33 [IQR 25–46] vs. 30 [IQR 24–42] years-old, p = 0.042) with a higher prevalence in the female sex (80.5% vs. 62.2%, p < 0.001) when compared to those who did not present cognitive symptoms, as well as a lower prevalence of smoking (8.7% vs. 16.2%, p = 0.024). Furthermore, patients with persistent cognitive symptoms were more likely to have been infected during the second wave of COVID-19 rather than the third (31.0% vs. 21.3%, p = 0.014). Patients who needed to seek in-person care during the acute phase of the disease were more likely to report post-acute cognitive symptoms (21.5% vs. 9.3%, p < 0,001). In multivariate logistic regression analysis, cognitive symptoms were associated with female sex (OR 2.24, CI 95% 1.41–3.57), fatigue (OR 2.33, CI 95% 1.19–4.56), depression (OR 5.37, CI 95% 2.19–13.15) and the need for seek in-person care during acute COVID-19 (OR 2.23, CI 95% 1.30–3.81).ConclusionIn this retrospective cohort of patients with mostly mild COVID-19, cognitive symptoms were present in 23.7% of patients with COVID-19 at 12 weeks after infection. Female sex, fatigue, depression and the need to seek in-person care during acute COVID-19 were the risk factors independently associated with this condition.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1282067/fullpost-acute COVID-19 syndromemental fatiguecognitive dysfunctionmemory disordersrisk factors |
| spellingShingle | Lívia Paula Freire Bonfim Thais Rotsen Correa Bruno Cabaleiro Cortizo Freire Thais Marques Pedroso Thais Marques Pedroso Daniella Nunes Pereira Thalita Baptisteli Fernandes Luciane Kopittke Clara Rodrigues Alves de Oliveira Clara Rodrigues Alves de Oliveira Antonio Lucio Teixeira Antonio Lucio Teixeira Milena Soriano Marcolino Milena Soriano Marcolino Milena Soriano Marcolino Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study Frontiers in Public Health post-acute COVID-19 syndrome mental fatigue cognitive dysfunction memory disorders risk factors |
| title | Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study |
| title_full | Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study |
| title_fullStr | Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study |
| title_full_unstemmed | Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study |
| title_short | Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study |
| title_sort | post covid 19 cognitive symptoms in patients assisted by a teleassistance service a retrospective cohort study |
| topic | post-acute COVID-19 syndrome mental fatigue cognitive dysfunction memory disorders risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1282067/full |
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