The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival
Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer, currently a leading cause of cancer-related death worldwide. The development of molecular biomarkers has led to novel treatment strategies and subsequent improvement in survival outcomes in all stages of the disease. ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Publicaciones Permanyer
2024-01-01
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| Series: | Barcelona Respiratory Network Reviews |
| Subjects: | |
| Online Access: | https://www.brnreviews.com/frame_eng.php?id=245 |
| _version_ | 1827308343690002432 |
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| author | Augusto Valdivia Ilaria Priano Nuria Pardo Enriqueta Felip |
| author_facet | Augusto Valdivia Ilaria Priano Nuria Pardo Enriqueta Felip |
| author_sort | Augusto Valdivia |
| collection | DOAJ |
| description | Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer, currently a leading cause of cancer-related death worldwide. The development of molecular biomarkers has led to novel treatment strategies and subsequent improvement in survival outcomes in all stages of the disease.
To select the best therapeutic strategy, an adequate tissue sample by means of core needle biopsies or cytological blocks is required in order to carry out PD-L1 expression by immunohistochemistry and Next-Generation Sequencing (NGS) panels. Pneumologists specializing in NSCLC diagnosis and staging have a paramount role in selecting the best tumoral site for analysis, as primary tumour, regional lymph nodes, and metastatic sites can be selected.
With this review, we aim to highlight the most important biomarkers used to guide treatment selection in NSCLC and show the improvement in survival outcomes with the implementation of these treatment strategies, from the metastatic setting, unresectable stage III, and resectable disease.
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| first_indexed | 2024-04-24T18:56:43Z |
| format | Article |
| id | doaj.art-d600cb5f789a42a399489af6661de192 |
| institution | Directory Open Access Journal |
| issn | 2462-3172 |
| language | English |
| last_indexed | 2024-04-24T18:56:43Z |
| publishDate | 2024-01-01 |
| publisher | Publicaciones Permanyer |
| record_format | Article |
| series | Barcelona Respiratory Network Reviews |
| spelling | doaj.art-d600cb5f789a42a399489af6661de1922024-03-26T17:07:11ZengPublicaciones PermanyerBarcelona Respiratory Network Reviews2462-31722024-01-0110110.23866/BRNRev:2024-M0105The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survivalAugusto Valdivia0Ilaria Priano1Nuria Pardo2Enriqueta Felip3Vall d’Hebron University Hospital, Medical OncologyVall d’Hebron University Hospital, Medical OncologyVall d’Hebron University Hospital, Medical OncologyVall d’Hebron University Hospital, Medical OncologyNon-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer, currently a leading cause of cancer-related death worldwide. The development of molecular biomarkers has led to novel treatment strategies and subsequent improvement in survival outcomes in all stages of the disease. To select the best therapeutic strategy, an adequate tissue sample by means of core needle biopsies or cytological blocks is required in order to carry out PD-L1 expression by immunohistochemistry and Next-Generation Sequencing (NGS) panels. Pneumologists specializing in NSCLC diagnosis and staging have a paramount role in selecting the best tumoral site for analysis, as primary tumour, regional lymph nodes, and metastatic sites can be selected. With this review, we aim to highlight the most important biomarkers used to guide treatment selection in NSCLC and show the improvement in survival outcomes with the implementation of these treatment strategies, from the metastatic setting, unresectable stage III, and resectable disease. https://www.brnreviews.com/frame_eng.php?id=245Biomarkers. Immunotherapy. Non-small-cell lung cancer. Targeted therapy. |
| spellingShingle | Augusto Valdivia Ilaria Priano Nuria Pardo Enriqueta Felip The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival Barcelona Respiratory Network Reviews Biomarkers. Immunotherapy. Non-small-cell lung cancer. Targeted therapy. |
| title | The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival |
| title_full | The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival |
| title_fullStr | The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival |
| title_full_unstemmed | The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival |
| title_short | The expanding importance of tissue sample analysis for biomarker testing in non-small cell lung cancer management and survival |
| title_sort | expanding importance of tissue sample analysis for biomarker testing in non small cell lung cancer management and survival |
| topic | Biomarkers. Immunotherapy. Non-small-cell lung cancer. Targeted therapy. |
| url | https://www.brnreviews.com/frame_eng.php?id=245 |
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