Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study
Abstract Background Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma remains uncertain. In this study, the associations of 25(OH) vit. D leve...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Clinical and Molecular Allergy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12948-020-00122-9 |
| _version_ | 1818029640949694464 |
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| author | Alireza Sharif Hamed Haddad Kashani Mohammad Reza Sharif |
| author_facet | Alireza Sharif Hamed Haddad Kashani Mohammad Reza Sharif |
| author_sort | Alireza Sharif |
| collection | DOAJ |
| description | Abstract Background Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma remains uncertain. In this study, the associations of 25(OH) vit. D levels with asthma and with the severity of asthma were evaluated. Methods This was a case–control study performed in 2015 in the city of Isfahan. In this study 520 children were studied. Children with asthma were classified as cases and children who were referred for reasons other than respiratory problems and asthma were considered as controls. Serum 25 (OH) vit. D levels were then examined and compared between the two groups. Differences among groups were stated to be statistically significant when P-values < 0.05. Results There were 260 asthmatic children and 260 controls in the present study. The mean 25 (OH) vit. D levels in the case group was 25.5 ± 16.62 and 16.76 ± 31.40 the control group and this difference was statistically significant (P < 0.05). 25(OH) vit. D levels were found to be 28.05 ± 16.98 in non-severe asthma and 21.41 ± 15.20 in severe asthma. Consequently 25(OH) vit. D level had inverse relationship with asthma severity (P = 0.002). Conclusions As the results of this study showed, the lower level of 25(OH) vit. D correlated with the higher severity of asthma manifestations. Therefore, it is recommended that 25(OH) vit. D levels get routinely checked especially in severe asthma cases and if the deficiency presents, appropriate therapeutic measures be used to reduce the asthma severity. |
| first_indexed | 2024-12-10T05:22:55Z |
| format | Article |
| id | doaj.art-d6038073310b4a4186247bf3d8ae0db3 |
| institution | Directory Open Access Journal |
| issn | 1476-7961 |
| language | English |
| last_indexed | 2024-12-10T05:22:55Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical and Molecular Allergy |
| spelling | doaj.art-d6038073310b4a4186247bf3d8ae0db32022-12-22T02:00:46ZengBMCClinical and Molecular Allergy1476-79612020-05-011811610.1186/s12948-020-00122-9Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control studyAlireza Sharif0Hamed Haddad Kashani1Mohammad Reza Sharif2Infectious Diseases Research Center, Kashan University of Medical SciencesAnatomical Sciences Research Center, Basic Sciences Research Institute, Kashan University of Medical SciencesInfectious Diseases Research Center, Kashan University of Medical SciencesAbstract Background Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma remains uncertain. In this study, the associations of 25(OH) vit. D levels with asthma and with the severity of asthma were evaluated. Methods This was a case–control study performed in 2015 in the city of Isfahan. In this study 520 children were studied. Children with asthma were classified as cases and children who were referred for reasons other than respiratory problems and asthma were considered as controls. Serum 25 (OH) vit. D levels were then examined and compared between the two groups. Differences among groups were stated to be statistically significant when P-values < 0.05. Results There were 260 asthmatic children and 260 controls in the present study. The mean 25 (OH) vit. D levels in the case group was 25.5 ± 16.62 and 16.76 ± 31.40 the control group and this difference was statistically significant (P < 0.05). 25(OH) vit. D levels were found to be 28.05 ± 16.98 in non-severe asthma and 21.41 ± 15.20 in severe asthma. Consequently 25(OH) vit. D level had inverse relationship with asthma severity (P = 0.002). Conclusions As the results of this study showed, the lower level of 25(OH) vit. D correlated with the higher severity of asthma manifestations. Therefore, it is recommended that 25(OH) vit. D levels get routinely checked especially in severe asthma cases and if the deficiency presents, appropriate therapeutic measures be used to reduce the asthma severity.http://link.springer.com/article/10.1186/s12948-020-00122-9AsthmaChildrenHealth25-Hydroxy vitamin DPatient |
| spellingShingle | Alireza Sharif Hamed Haddad Kashani Mohammad Reza Sharif Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study Clinical and Molecular Allergy Asthma Children Health 25-Hydroxy vitamin D Patient |
| title | Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study |
| title_full | Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study |
| title_fullStr | Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study |
| title_full_unstemmed | Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study |
| title_short | Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study |
| title_sort | association of 25 hydroxy vitamin d with asthma and its severity in children a case control study |
| topic | Asthma Children Health 25-Hydroxy vitamin D Patient |
| url | http://link.springer.com/article/10.1186/s12948-020-00122-9 |
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