COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda
<h4>Background</h4> Despite being a priority population for COVID-19 vaccination, limited data are available regarding acceptability of COVID-19 vaccines among people living with HIV (PLWH) in Sub-Saharan Africa. We described COVID-19 vaccine acceptability and factors associated with vac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718389/?tool=EBI |
| _version_ | 1811179029246509056 |
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| author | Richard Muhindo Stephen Okoboi Agnes Kiragga Rachel King Walter Joseph Arinaitwe Barbara Castelnuovo |
| author_facet | Richard Muhindo Stephen Okoboi Agnes Kiragga Rachel King Walter Joseph Arinaitwe Barbara Castelnuovo |
| author_sort | Richard Muhindo |
| collection | DOAJ |
| description | <h4>Background</h4> Despite being a priority population for COVID-19 vaccination, limited data are available regarding acceptability of COVID-19 vaccines among people living with HIV (PLWH) in Sub-Saharan Africa. We described COVID-19 vaccine acceptability and factors associated with vaccine acceptability among PLWH in Uganda. <h4>Methods</h4> This was a cross-sectional study conducted among PLWH, aged ≥18 years, enrolled participants who were seeking HIV care from six purposely selected accredited ART clinics in Kampala. We obtained data on vaccine acceptability defined as willingness to accept any of the available COVID-19 vaccines using interviewer-administered questionnaires. In addition, we assessed vaccination status, complacency regarding COVID-19 disease, vaccine confidence, and vaccine convenience. Factors associated with COVID-19 vaccine acceptability were evaluated using modified Poisson regression with robust standard errors. <h4>Results</h4> We enrolled 767 participants of whom 485 (63%) were women. The median age was 33 years [interquartile range (IQR) 28–40] for women and 40 years [IQR], (34–47) for men. Of the respondents 534 (69.6%,95% confidence interval [CI]: 66.3%-72.8%) reported receiving at least one vaccine dose, with women significantly more likely than men to have been vaccinated (73% vs. 63%; p = 0.003). Among the unvaccinated 169 (72.7%, 95% CI: 66.6%-78.0%) were willing to accept vaccination, had greater vaccine confidence (85.9% had strong belief that the vaccines were effective; 81.9% that they were beneficial and 71% safe for PLWH; 90.5% had trust in health care professionals or 77.4% top government officials), and believed that it would be easy to obtain a vaccine if one decided to be vaccinated (83.6%). Vaccine acceptability was positively associated with greater vaccine confidence (adjusted prevalence ratio [aPR] 1.44; 95% CI: 1.08–1.90), and positive perception that it would be easy to obtain a vaccine (aPR 1.57; 95% CI: 1.26–1.96). <h4>Conclusion</h4> vaccine acceptance was high among this cohort of PLWH, and was positively associated with greater vaccine confidence, and perceived easiness (convince) to obtained the vaccine. Building vaccine confidence and making vaccines easily accessible should be a priority for vaccination programs targeting PLWH. |
| first_indexed | 2024-04-11T06:28:45Z |
| format | Article |
| id | doaj.art-d604f95564854297ad4bc2516d1bbaef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T06:28:45Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d604f95564854297ad4bc2516d1bbaef2022-12-22T04:40:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712COVID-19 vaccine acceptability, and uptake among people living with HIV in UgandaRichard MuhindoStephen OkoboiAgnes KiraggaRachel KingWalter Joseph ArinaitweBarbara Castelnuovo<h4>Background</h4> Despite being a priority population for COVID-19 vaccination, limited data are available regarding acceptability of COVID-19 vaccines among people living with HIV (PLWH) in Sub-Saharan Africa. We described COVID-19 vaccine acceptability and factors associated with vaccine acceptability among PLWH in Uganda. <h4>Methods</h4> This was a cross-sectional study conducted among PLWH, aged ≥18 years, enrolled participants who were seeking HIV care from six purposely selected accredited ART clinics in Kampala. We obtained data on vaccine acceptability defined as willingness to accept any of the available COVID-19 vaccines using interviewer-administered questionnaires. In addition, we assessed vaccination status, complacency regarding COVID-19 disease, vaccine confidence, and vaccine convenience. Factors associated with COVID-19 vaccine acceptability were evaluated using modified Poisson regression with robust standard errors. <h4>Results</h4> We enrolled 767 participants of whom 485 (63%) were women. The median age was 33 years [interquartile range (IQR) 28–40] for women and 40 years [IQR], (34–47) for men. Of the respondents 534 (69.6%,95% confidence interval [CI]: 66.3%-72.8%) reported receiving at least one vaccine dose, with women significantly more likely than men to have been vaccinated (73% vs. 63%; p = 0.003). Among the unvaccinated 169 (72.7%, 95% CI: 66.6%-78.0%) were willing to accept vaccination, had greater vaccine confidence (85.9% had strong belief that the vaccines were effective; 81.9% that they were beneficial and 71% safe for PLWH; 90.5% had trust in health care professionals or 77.4% top government officials), and believed that it would be easy to obtain a vaccine if one decided to be vaccinated (83.6%). Vaccine acceptability was positively associated with greater vaccine confidence (adjusted prevalence ratio [aPR] 1.44; 95% CI: 1.08–1.90), and positive perception that it would be easy to obtain a vaccine (aPR 1.57; 95% CI: 1.26–1.96). <h4>Conclusion</h4> vaccine acceptance was high among this cohort of PLWH, and was positively associated with greater vaccine confidence, and perceived easiness (convince) to obtained the vaccine. Building vaccine confidence and making vaccines easily accessible should be a priority for vaccination programs targeting PLWH.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718389/?tool=EBI |
| spellingShingle | Richard Muhindo Stephen Okoboi Agnes Kiragga Rachel King Walter Joseph Arinaitwe Barbara Castelnuovo COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda PLoS ONE |
| title | COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda |
| title_full | COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda |
| title_fullStr | COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda |
| title_full_unstemmed | COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda |
| title_short | COVID-19 vaccine acceptability, and uptake among people living with HIV in Uganda |
| title_sort | covid 19 vaccine acceptability and uptake among people living with hiv in uganda |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718389/?tool=EBI |
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