Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis
Abstract Background Epicardial fat tissue (EFT) is the visceral fat distributed along the coronary arteries between the pericardium and the myocardium. Increases in EFT are closely related to the occurrence of diabetes mellitus (DM) and cardiovascular disease. To further understand the link between...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-01-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-019-0807-3 |
| _version_ | 1828805745649385472 |
|---|---|
| author | Yingrui Li Bin Liu Yu Li Xiaodong Jing Songbai Deng Yulin Yan Qiang She |
| author_facet | Yingrui Li Bin Liu Yu Li Xiaodong Jing Songbai Deng Yulin Yan Qiang She |
| author_sort | Yingrui Li |
| collection | DOAJ |
| description | Abstract Background Epicardial fat tissue (EFT) is the visceral fat distributed along the coronary arteries between the pericardium and the myocardium. Increases in EFT are closely related to the occurrence of diabetes mellitus (DM) and cardiovascular disease. To further understand the link between EFT and DM, we conducted a meta-analysis of the relevant literature. Methods We systematically searched electronic databases for studies on EFT performed in DM patients and published up to 30 September 2018. We included data on EFT in a DM patient group and a non-DM control group. We then assessed the effect of DM on EFT by meta-analysis and trial sequential analysis (TSA). All statistical analyses were performed using Stata 12.0 and TSA software. Results A total of 13 studies (n = 1102 patients) were included in the final analysis. Compared with the control group, DM patients had significantly higher EFT (SMD: 1.23; 95% CI 0.98, 1.48; P = 0.000; TSA-adjusted 95% CI 0.91, 2.13; P < 0.0001). The TSA indicated that the available samples were sufficient and confirmed that firm evidence was reached. According to the regression analysis and subgroup analyses, DM typing, EFT ultrasound measurements, total cholesterol (TC) and triglyceride (TG) levels were confounding factors that significantly affected our results. Conclusions Our meta-analysis suggests that the amount of EFT is significantly higher in DM patients than in non-DM patients. |
| first_indexed | 2024-12-12T07:59:47Z |
| format | Article |
| id | doaj.art-d60512a5420842a5bd36b09ea05cdf66 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-12T07:59:47Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-d60512a5420842a5bd36b09ea05cdf662022-12-22T00:32:11ZengBMCCardiovascular Diabetology1475-28402019-01-0118111010.1186/s12933-019-0807-3Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysisYingrui Li0Bin Liu1Yu Li2Xiaodong Jing3Songbai Deng4Yulin Yan5Qiang She6Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract Background Epicardial fat tissue (EFT) is the visceral fat distributed along the coronary arteries between the pericardium and the myocardium. Increases in EFT are closely related to the occurrence of diabetes mellitus (DM) and cardiovascular disease. To further understand the link between EFT and DM, we conducted a meta-analysis of the relevant literature. Methods We systematically searched electronic databases for studies on EFT performed in DM patients and published up to 30 September 2018. We included data on EFT in a DM patient group and a non-DM control group. We then assessed the effect of DM on EFT by meta-analysis and trial sequential analysis (TSA). All statistical analyses were performed using Stata 12.0 and TSA software. Results A total of 13 studies (n = 1102 patients) were included in the final analysis. Compared with the control group, DM patients had significantly higher EFT (SMD: 1.23; 95% CI 0.98, 1.48; P = 0.000; TSA-adjusted 95% CI 0.91, 2.13; P < 0.0001). The TSA indicated that the available samples were sufficient and confirmed that firm evidence was reached. According to the regression analysis and subgroup analyses, DM typing, EFT ultrasound measurements, total cholesterol (TC) and triglyceride (TG) levels were confounding factors that significantly affected our results. Conclusions Our meta-analysis suggests that the amount of EFT is significantly higher in DM patients than in non-DM patients.http://link.springer.com/article/10.1186/s12933-019-0807-3Epicardial fat tissueDiabetes mellitusMeta-analysis |
| spellingShingle | Yingrui Li Bin Liu Yu Li Xiaodong Jing Songbai Deng Yulin Yan Qiang She Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis Cardiovascular Diabetology Epicardial fat tissue Diabetes mellitus Meta-analysis |
| title | Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis |
| title_full | Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis |
| title_fullStr | Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis |
| title_full_unstemmed | Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis |
| title_short | Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis |
| title_sort | epicardial fat tissue in patients with diabetes mellitus a systematic review and meta analysis |
| topic | Epicardial fat tissue Diabetes mellitus Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12933-019-0807-3 |
| work_keys_str_mv | AT yingruili epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis AT binliu epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis AT yuli epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis AT xiaodongjing epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis AT songbaideng epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis AT yulinyan epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis AT qiangshe epicardialfattissueinpatientswithdiabetesmellitusasystematicreviewandmetaanalysis |