Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity
AbstractBackground:Morbid obesity is directly related to deterioration in cardiorespiratory capacity, including changes in cardiovascular autonomic modulation.Objective:This study aimed to assess the cardiovascular autonomic function in morbidly obese individuals.Methods:Cross-sectional study, inclu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
2015-01-01
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| Series: | Arquivos Brasileiros de Cardiologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015005050125&lng=en&tlng=en |
| _version_ | 1818528535805952000 |
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| author | Maurício de Sant Anna Junior João Regis Ivar Carneiro Renata Ferreira Carvalhal Diego de Faria Magalhães Torres Gustavo Gavina da Cruz José Carlos do Vale Quaresma Jocemir Ronaldo Lugon Fernando Silva Guimarães |
| author_facet | Maurício de Sant Anna Junior João Regis Ivar Carneiro Renata Ferreira Carvalhal Diego de Faria Magalhães Torres Gustavo Gavina da Cruz José Carlos do Vale Quaresma Jocemir Ronaldo Lugon Fernando Silva Guimarães |
| author_sort | Maurício de Sant Anna Junior |
| collection | DOAJ |
| description | AbstractBackground:Morbid obesity is directly related to deterioration in cardiorespiratory capacity, including changes in cardiovascular autonomic modulation.Objective:This study aimed to assess the cardiovascular autonomic function in morbidly obese individuals.Methods:Cross-sectional study, including two groups of participants: Group I, composed by 50 morbidly obese subjects, and Group II, composed by 30 nonobese subjects. The autonomic function was assessed by heart rate variability in the time domain (standard deviation of all normal RR intervals [SDNN]; standard deviation of the normal R-R intervals [SDNN]; square root of the mean squared differences of successive R-R intervals [RMSSD]; and the percentage of interval differences of successive R-R intervals greater than 50 milliseconds [pNN50] than the adjacent interval), and in the frequency domain (high frequency [HF]; low frequency [LF]: integration of power spectral density function in high frequency and low frequency ranges respectively). Between-group comparisons were performed by the Student’s t-test, with a level of significance of 5%.Results:Obese subjects had lower values of SDNN (40.0 ± 18.0 ms vs. 70.0 ± 27.8 ms; p = 0.0004), RMSSD (23.7 ± 13.0 ms vs. 40.3 ± 22.4 ms; p = 0.0030), pNN50 (14.8 ± 10.4 % vs. 25.9 ± 7.2%; p = 0.0061) and HF (30.0 ± 17.5 Hz vs. 51.7 ± 25.5 Hz; p = 0.0023) than controls. Mean LF/HF ratio was higher in Group I (5.0 ± 2.8 vs. 1.0 ± 0.9; p = 0.0189), indicating changes in the sympathovagal balance. No statistical difference in LF was observed between Group I and Group II (50.1 ± 30.2 Hz vs. 40.9 ± 23.9 Hz; p = 0.9013).Conclusion:morbidly obese individuals have increased sympathetic activity and reduced parasympathetic activity, featuring cardiovascular autonomic dysfunction. |
| first_indexed | 2024-12-11T06:51:12Z |
| format | Article |
| id | doaj.art-d605ffe0c4354dc68f733f212edf3df3 |
| institution | Directory Open Access Journal |
| issn | 1678-4170 |
| language | English |
| last_indexed | 2024-12-11T06:51:12Z |
| publishDate | 2015-01-01 |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-d605ffe0c4354dc68f733f212edf3df32022-12-22T01:16:54ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-41702015-01-0100010.5935/abc.20150125S0066-782X2015005050125Cardiovascular Autonomic Dysfunction in Patients with Morbid ObesityMaurício de Sant Anna JuniorJoão Regis Ivar CarneiroRenata Ferreira CarvalhalDiego de Faria Magalhães TorresGustavo Gavina da CruzJosé Carlos do Vale QuaresmaJocemir Ronaldo LugonFernando Silva GuimarãesAbstractBackground:Morbid obesity is directly related to deterioration in cardiorespiratory capacity, including changes in cardiovascular autonomic modulation.Objective:This study aimed to assess the cardiovascular autonomic function in morbidly obese individuals.Methods:Cross-sectional study, including two groups of participants: Group I, composed by 50 morbidly obese subjects, and Group II, composed by 30 nonobese subjects. The autonomic function was assessed by heart rate variability in the time domain (standard deviation of all normal RR intervals [SDNN]; standard deviation of the normal R-R intervals [SDNN]; square root of the mean squared differences of successive R-R intervals [RMSSD]; and the percentage of interval differences of successive R-R intervals greater than 50 milliseconds [pNN50] than the adjacent interval), and in the frequency domain (high frequency [HF]; low frequency [LF]: integration of power spectral density function in high frequency and low frequency ranges respectively). Between-group comparisons were performed by the Student’s t-test, with a level of significance of 5%.Results:Obese subjects had lower values of SDNN (40.0 ± 18.0 ms vs. 70.0 ± 27.8 ms; p = 0.0004), RMSSD (23.7 ± 13.0 ms vs. 40.3 ± 22.4 ms; p = 0.0030), pNN50 (14.8 ± 10.4 % vs. 25.9 ± 7.2%; p = 0.0061) and HF (30.0 ± 17.5 Hz vs. 51.7 ± 25.5 Hz; p = 0.0023) than controls. Mean LF/HF ratio was higher in Group I (5.0 ± 2.8 vs. 1.0 ± 0.9; p = 0.0189), indicating changes in the sympathovagal balance. No statistical difference in LF was observed between Group I and Group II (50.1 ± 30.2 Hz vs. 40.9 ± 23.9 Hz; p = 0.9013).Conclusion:morbidly obese individuals have increased sympathetic activity and reduced parasympathetic activity, featuring cardiovascular autonomic dysfunction.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015005050125&lng=en&tlng=enObesidade MórbidaDoenças CardiovascularesFatores de Risco; Doença Cardiopulmonar / complicaçõesFrequência Cardíaca |
| spellingShingle | Maurício de Sant Anna Junior João Regis Ivar Carneiro Renata Ferreira Carvalhal Diego de Faria Magalhães Torres Gustavo Gavina da Cruz José Carlos do Vale Quaresma Jocemir Ronaldo Lugon Fernando Silva Guimarães Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity Arquivos Brasileiros de Cardiologia Obesidade Mórbida Doenças Cardiovasculares Fatores de Risco; Doença Cardiopulmonar / complicações Frequência Cardíaca |
| title | Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity |
| title_full | Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity |
| title_fullStr | Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity |
| title_full_unstemmed | Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity |
| title_short | Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity |
| title_sort | cardiovascular autonomic dysfunction in patients with morbid obesity |
| topic | Obesidade Mórbida Doenças Cardiovasculares Fatores de Risco; Doença Cardiopulmonar / complicações Frequência Cardíaca |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015005050125&lng=en&tlng=en |
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