Brain network hierarchy reorganization in subthreshold depression
Background: Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD. Methods: A total of 43...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224000330 |
| _version_ | 1797249176506990592 |
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| author | Xiaolong Yin Junchao Yang Qing Xiang Lixin Peng Jian Song Shengxiang Liang Jingsong Wu |
| author_facet | Xiaolong Yin Junchao Yang Qing Xiang Lixin Peng Jian Song Shengxiang Liang Jingsong Wu |
| author_sort | Xiaolong Yin |
| collection | DOAJ |
| description | Background: Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD. Methods: A total of 43 patients with StD and 43 healthy controls matched for age, gender and years of education participated in this study. Alterations in the hierarchy of StD brain networks were depicted by connectome gradient analysis. We assessed changes in network hierarchy by comparing gradient scores in each network in patients with StD and healthy controls. The study compared different brain subdivisions if there was a different network. Finally, we analysed the relationship between the altered gradient scores and clinical characteristics. Results: Patients with StD had contracted network hierarchy and suppressed cortical range gradients. In the principal gradient, the gradient scores of default mode network were significantly reduced in patients with StD compared to controls. In the default network, the subdivisions of reduced gradient scores were mainly located in the precuneus, superior temporal gyrus, and anterior and posterior cingulate gyrus. Reduced gradient scores in the default mode network, the anterior and posterior cingulate gyrus were correlated with severity of depression. Conclusions: The network hierarchy of the StD changed and was significantly correlated with depressive symptoms and severity. These results provided new insights into further understanding of the neural mechanisms of StD. |
| first_indexed | 2024-04-24T20:26:19Z |
| format | Article |
| id | doaj.art-d607265f39c14a98bc812266b9d08e56 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-24T20:26:19Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-d607265f39c14a98bc812266b9d08e562024-03-22T05:39:17ZengElsevierNeuroImage: Clinical2213-15822024-01-0142103594Brain network hierarchy reorganization in subthreshold depressionXiaolong Yin0Junchao Yang1Qing Xiang2Lixin Peng3Jian Song4Shengxiang Liang5Jingsong Wu6National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Corresponding authors at: National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China (S. Liang).College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Corresponding authors at: National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China (S. Liang).Background: Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD. Methods: A total of 43 patients with StD and 43 healthy controls matched for age, gender and years of education participated in this study. Alterations in the hierarchy of StD brain networks were depicted by connectome gradient analysis. We assessed changes in network hierarchy by comparing gradient scores in each network in patients with StD and healthy controls. The study compared different brain subdivisions if there was a different network. Finally, we analysed the relationship between the altered gradient scores and clinical characteristics. Results: Patients with StD had contracted network hierarchy and suppressed cortical range gradients. In the principal gradient, the gradient scores of default mode network were significantly reduced in patients with StD compared to controls. In the default network, the subdivisions of reduced gradient scores were mainly located in the precuneus, superior temporal gyrus, and anterior and posterior cingulate gyrus. Reduced gradient scores in the default mode network, the anterior and posterior cingulate gyrus were correlated with severity of depression. Conclusions: The network hierarchy of the StD changed and was significantly correlated with depressive symptoms and severity. These results provided new insights into further understanding of the neural mechanisms of StD.http://www.sciencedirect.com/science/article/pii/S2213158224000330Subthreshold depressionGradientDefault mode networkHierarchy |
| spellingShingle | Xiaolong Yin Junchao Yang Qing Xiang Lixin Peng Jian Song Shengxiang Liang Jingsong Wu Brain network hierarchy reorganization in subthreshold depression NeuroImage: Clinical Subthreshold depression Gradient Default mode network Hierarchy |
| title | Brain network hierarchy reorganization in subthreshold depression |
| title_full | Brain network hierarchy reorganization in subthreshold depression |
| title_fullStr | Brain network hierarchy reorganization in subthreshold depression |
| title_full_unstemmed | Brain network hierarchy reorganization in subthreshold depression |
| title_short | Brain network hierarchy reorganization in subthreshold depression |
| title_sort | brain network hierarchy reorganization in subthreshold depression |
| topic | Subthreshold depression Gradient Default mode network Hierarchy |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224000330 |
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