Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast
While yeast has been extensively used as a model system for analysing protein–protein and genetic interactions, in the context of bacterial pathogenesis, the use of yeast‐based tools has largely been limited to identifying interactions between pathogen effectors and host targets. In their recent wor...
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| Format: | Article |
| Language: | English |
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Springer Nature
2017-01-01
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| Series: | Molecular Systems Biology |
| Online Access: | https://doi.org/10.15252/msb.20167447 |
| _version_ | 1797225446600867840 |
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| author | Alan Huett |
| author_facet | Alan Huett |
| author_sort | Alan Huett |
| collection | DOAJ |
| description | While yeast has been extensively used as a model system for analysing protein–protein and genetic interactions, in the context of bacterial pathogenesis, the use of yeast‐based tools has largely been limited to identifying interactions between pathogen effectors and host targets. In their recent work, Ensminger and colleagues (Urbanus et al, ) use the combinatorial power of yeast genetics to systematically screen all known Legionella pneumophila effector proteins for effector–effector interactions. They provide new insights into how bacterial effectors balance host cell perturbation and describe mechanisms used by “meta‐effectors” to directly modulate target effector activity. |
| first_indexed | 2024-03-13T03:11:19Z |
| format | Article |
| id | doaj.art-d608fab9ed0742008f64700d798f9f4c |
| institution | Directory Open Access Journal |
| issn | 1744-4292 |
| language | English |
| last_indexed | 2024-04-24T14:09:09Z |
| publishDate | 2017-01-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj.art-d608fab9ed0742008f64700d798f9f4c2024-04-03T09:38:11ZengSpringer NatureMolecular Systems Biology1744-42922017-01-01131n/an/a10.15252/msb.20167447Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeastAlan Huett0School of Life Sciences D102 Medical School Queens Medical Centre University of Nottingham Nottingham UKWhile yeast has been extensively used as a model system for analysing protein–protein and genetic interactions, in the context of bacterial pathogenesis, the use of yeast‐based tools has largely been limited to identifying interactions between pathogen effectors and host targets. In their recent work, Ensminger and colleagues (Urbanus et al, ) use the combinatorial power of yeast genetics to systematically screen all known Legionella pneumophila effector proteins for effector–effector interactions. They provide new insights into how bacterial effectors balance host cell perturbation and describe mechanisms used by “meta‐effectors” to directly modulate target effector activity.https://doi.org/10.15252/msb.20167447 |
| spellingShingle | Alan Huett Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast Molecular Systems Biology |
| title | Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast |
| title_full | Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast |
| title_fullStr | Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast |
| title_full_unstemmed | Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast |
| title_short | Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast |
| title_sort | combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast |
| url | https://doi.org/10.15252/msb.20167447 |
| work_keys_str_mv | AT alanhuett combinatorialactionsofbacterialeffectorsrevealedbyexploitinggenetictoolsinyeast |