Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation

Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation

<p>Abstract</p> <p>Group I metabotropic glutamate receptors (mGluRs) are coupled via Gα<sub>q/11 </sub>to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of...

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Bibliographic Details
Main Authors: Nicodemo Alexander A, Pampillo Macarena, Ferreira Lucimar T, Dale Lianne B, Cregan Tamara, Ribeiro Fabiola M, Ferguson Stephen SG
Format: Article
Language:English
Published: BMC 2010-01-01
Series:Molecular Brain
Online Access:http://www.molecularbrain.com/content/3/1/4

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