Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration
Background: Glioma is the result of malignant transformation of glial cells in the white matter of the brain or spinal cord and accounts for approximately 80% of all intracranial malignancies. Cathepsin A (CTSA) is highly expressed in a variety of tumor tissues, but its role in glioma is poorly stud...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2022-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582204459Z.pdf |
| _version_ | 1811194247929397248 |
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| author | Zhang Ming Huang Jun Wang Yunfei Nie Qingbin Zhang Xinye Yang Yufeng Mao Gengsheng |
| author_facet | Zhang Ming Huang Jun Wang Yunfei Nie Qingbin Zhang Xinye Yang Yufeng Mao Gengsheng |
| author_sort | Zhang Ming |
| collection | DOAJ |
| description | Background: Glioma is the result of malignant transformation of glial cells in the white matter of the brain or spinal cord and accounts for approximately 80% of all intracranial malignancies. Cathepsin A (CTSA) is highly expressed in a variety of tumor tissues, but its role in glioma is poorly studied. This study analyses the relationship between CTSA, and glioma based on The Cancer Genome Atlas (TCGA). Methods: Data for glioma patients were collected from TCGA. The expression level of CTSA was compared between paired glioma tissues and normal tissues with Wilcoxon rank-sum test. In addition, the Wilcoxon ranksum test was also applied to analyze the relationship between clinicopathologic features and CTSA expression. Kaplan-Meier Plotter was applied to analyze OS, DSS and PFI. Immuno-infiltration analysis of BLCA was performed by single sample gene set enrichment analysis (ssGSEA) in the "GSVA" R package. Results: The CTSA was overexpressed in glioma tissues compared to normal tissues (P<0.001). The high expression of CTSA was significantly related to 1p/19q codeletion, IDH, WHO grade and histological type. Kaplan-Meier survival analysis showed that patients with glioma characterized with high expressed CTSA had a poorer OS (HR=2.16 P<0.001), DSS (HR=2.17 P<0.001) and PFI (HR=1.48 P<0.001) than patients with low CTSA expression. Moreover, High expressed CTSA was associated with immune cell infiltration. Conclusions: CTSA may serve as a candidate prognostic biomarker for determining prognosis associated with immune infiltration in glioma. |
| first_indexed | 2024-04-12T00:22:46Z |
| format | Article |
| id | doaj.art-d60c3dfd273a4ac68957c446804a315a |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-12T00:22:46Z |
| publishDate | 2022-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-d60c3dfd273a4ac68957c446804a315a2022-12-22T03:55:40ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662022-01-0141445946510.5937/jomb0-356771452-82582204459ZCathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltrationZhang Ming0Huang Jun1Wang Yunfei2Nie Qingbin3Zhang Xinye4Yang Yufeng5Mao Gengsheng6The Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaThe Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaThe Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaThe Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaThe Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaThe Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaThe Third Medical Centre Chinese PLA (People's Liberation Army) General Hospital, Department of Neurosurgery, Beijing, ChinaBackground: Glioma is the result of malignant transformation of glial cells in the white matter of the brain or spinal cord and accounts for approximately 80% of all intracranial malignancies. Cathepsin A (CTSA) is highly expressed in a variety of tumor tissues, but its role in glioma is poorly studied. This study analyses the relationship between CTSA, and glioma based on The Cancer Genome Atlas (TCGA). Methods: Data for glioma patients were collected from TCGA. The expression level of CTSA was compared between paired glioma tissues and normal tissues with Wilcoxon rank-sum test. In addition, the Wilcoxon ranksum test was also applied to analyze the relationship between clinicopathologic features and CTSA expression. Kaplan-Meier Plotter was applied to analyze OS, DSS and PFI. Immuno-infiltration analysis of BLCA was performed by single sample gene set enrichment analysis (ssGSEA) in the "GSVA" R package. Results: The CTSA was overexpressed in glioma tissues compared to normal tissues (P<0.001). The high expression of CTSA was significantly related to 1p/19q codeletion, IDH, WHO grade and histological type. Kaplan-Meier survival analysis showed that patients with glioma characterized with high expressed CTSA had a poorer OS (HR=2.16 P<0.001), DSS (HR=2.17 P<0.001) and PFI (HR=1.48 P<0.001) than patients with low CTSA expression. Moreover, High expressed CTSA was associated with immune cell infiltration. Conclusions: CTSA may serve as a candidate prognostic biomarker for determining prognosis associated with immune infiltration in glioma.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582204459Z.pdfcathepsin agliomaprognostic biomarkerimmune infiltration |
| spellingShingle | Zhang Ming Huang Jun Wang Yunfei Nie Qingbin Zhang Xinye Yang Yufeng Mao Gengsheng Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration Journal of Medical Biochemistry cathepsin a glioma prognostic biomarker immune infiltration |
| title | Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration |
| title_full | Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration |
| title_fullStr | Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration |
| title_full_unstemmed | Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration |
| title_short | Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration |
| title_sort | cathepsin a upregulation in glioma a potential therapeutic target associated with immune infiltration |
| topic | cathepsin a glioma prognostic biomarker immune infiltration |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582204459Z.pdf |
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