Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/8/1233 |
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| author | Marina A. Semenova Rita V. Chertkova Mikhail P. Kirpichnikov Dmitry A. Dolgikh |
| author_facet | Marina A. Semenova Rita V. Chertkova Mikhail P. Kirpichnikov Dmitry A. Dolgikh |
| author_sort | Marina A. Semenova |
| collection | DOAJ |
| description | Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin and mitochondrial cytochrome <i>c</i> may serve as at least one of the mechanisms of neuroglobin-mediated neuroprotection. Interestingly, neuroglobin and cytochrome <i>c</i> possibly can interact with or without electron transfer both in the cytoplasm and within the mitochondria. This review provides a general picture of molecular interactions between neuroglobin and cytochrome <i>c</i> based on the recent experimental and computational work on neuroglobin and cytochrome <i>c</i> interactions. |
| first_indexed | 2024-03-11T00:05:50Z |
| format | Article |
| id | doaj.art-d60e9861db01462d81fabeab39279148 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T00:05:50Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d60e9861db01462d81fabeab392791482023-11-19T00:24:05ZengMDPI AGBiomolecules2218-273X2023-08-01138123310.3390/biom13081233Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal CellsMarina A. Semenova0Rita V. Chertkova1Mikhail P. Kirpichnikov2Dmitry A. Dolgikh3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho–Maklaya St. 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho–Maklaya St. 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho–Maklaya St. 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho–Maklaya St. 16/10, 117997 Moscow, RussiaNeuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin and mitochondrial cytochrome <i>c</i> may serve as at least one of the mechanisms of neuroglobin-mediated neuroprotection. Interestingly, neuroglobin and cytochrome <i>c</i> possibly can interact with or without electron transfer both in the cytoplasm and within the mitochondria. This review provides a general picture of molecular interactions between neuroglobin and cytochrome <i>c</i> based on the recent experimental and computational work on neuroglobin and cytochrome <i>c</i> interactions.https://www.mdpi.com/2218-273X/13/8/1233neuroglobinneuroprotectioncytochrome <i>c</i>heme proteinsprotein–protein interactionapoptosis |
| spellingShingle | Marina A. Semenova Rita V. Chertkova Mikhail P. Kirpichnikov Dmitry A. Dolgikh Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells Biomolecules neuroglobin neuroprotection cytochrome <i>c</i> heme proteins protein–protein interaction apoptosis |
| title | Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells |
| title_full | Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells |
| title_fullStr | Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells |
| title_full_unstemmed | Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells |
| title_short | Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells |
| title_sort | molecular interactions between neuroglobin and cytochrome i c i possible mechanisms of antiapoptotic defense in neuronal cells |
| topic | neuroglobin neuroprotection cytochrome <i>c</i> heme proteins protein–protein interaction apoptosis |
| url | https://www.mdpi.com/2218-273X/13/8/1233 |
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