Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction
Extensive clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular disease (CVD), including coronary disease, heart failure, hypertension, cerebrovascular disease, atrial fibrillation, ventricular arrhythmias, and sudden death. In addition, increasing knowledge...
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/24/5792 |
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| author | Grzegorz Józef Nowicki Barbara Ślusarska Maciej Polak Katarzyna Naylor Tomasz Kocki |
| author_facet | Grzegorz Józef Nowicki Barbara Ślusarska Maciej Polak Katarzyna Naylor Tomasz Kocki |
| author_sort | Grzegorz Józef Nowicki |
| collection | DOAJ |
| description | Extensive clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular disease (CVD), including coronary disease, heart failure, hypertension, cerebrovascular disease, atrial fibrillation, ventricular arrhythmias, and sudden death. In addition, increasing knowledge of regulatory peptides has allowed an assessment of their role in various non-communicable diseases, including CVD. The study assessed the concentration of kallistatin and afamin in the blood serum of patients after a myocardial infarction and without a cardiovascular event, and determined the relationship between the concentration of kallistatin and afamin and the anthropometric indicators of being overweight and of obesity in these groups. Serum kallistatin and afamin were quantified by ELISA tests in a cross-sectional study of 160 patients who were divided into two groups: study group (SG) (<i>n</i> = 80) and another with no cardiovascular event (CG) (<i>n</i> = 80). Serum kallistatin concentration was significantly higher in the SG (<i>p</i> < 0.001), while the level of afamin was significantly lower in this group (<i>p</i> < 0.001). In addition, a positive correlation was observed in the SG between the afamin concentration and the waist to hip ratio (WHR), lipid accumulation product (LAP) and the triglyceride glucose index (TyG index). In the CG, the concentration of kallistatin positively correlated with the LAP and TyG index, while the concentration of afamin positively correlated with all the examined parameters: body mass index (BMI), waist circumference (WC), hip circumference (HC), waist to hip ratio (WHtR), visceral adiposity index (VAI), LAP and TyG index. Serum kallistatin and afamin concentrations are associated with the anthropometric parameters related to being overweight and to obesity, especially to those describing the visceral distribution of adipose tissue and metabolic disorders related to excessive fatness. |
| first_indexed | 2024-03-10T03:52:05Z |
| format | Article |
| id | doaj.art-d60ee092f637472395bee7c3f46d9902 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:52:05Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d60ee092f637472395bee7c3f46d99022023-11-23T08:56:17ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011024579210.3390/jcm10245792Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial InfarctionGrzegorz Józef Nowicki0Barbara Ślusarska1Maciej Polak2Katarzyna Naylor3Tomasz Kocki4Department of Family and Geriatric Nursing, Medical University of Lublin, Staszica 6 Str., 20-081 Lublin, PolandDepartment of Family and Geriatric Nursing, Medical University of Lublin, Staszica 6 Str., 20-081 Lublin, PolandDepartment of Epidemiology and Population Studies, Jagiellonian University Medical College, Grzegórzecka 20 Str., 31-531 Krakow, PolandIndependent Laboratory of Emergency Medicine, Centre for Medical Simulation, Medical University of Lublin, Chodźki 4 Str., 20-093 Lublin, PolandChair and Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b Str., 20-090 Lublin, PolandExtensive clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular disease (CVD), including coronary disease, heart failure, hypertension, cerebrovascular disease, atrial fibrillation, ventricular arrhythmias, and sudden death. In addition, increasing knowledge of regulatory peptides has allowed an assessment of their role in various non-communicable diseases, including CVD. The study assessed the concentration of kallistatin and afamin in the blood serum of patients after a myocardial infarction and without a cardiovascular event, and determined the relationship between the concentration of kallistatin and afamin and the anthropometric indicators of being overweight and of obesity in these groups. Serum kallistatin and afamin were quantified by ELISA tests in a cross-sectional study of 160 patients who were divided into two groups: study group (SG) (<i>n</i> = 80) and another with no cardiovascular event (CG) (<i>n</i> = 80). Serum kallistatin concentration was significantly higher in the SG (<i>p</i> < 0.001), while the level of afamin was significantly lower in this group (<i>p</i> < 0.001). In addition, a positive correlation was observed in the SG between the afamin concentration and the waist to hip ratio (WHR), lipid accumulation product (LAP) and the triglyceride glucose index (TyG index). In the CG, the concentration of kallistatin positively correlated with the LAP and TyG index, while the concentration of afamin positively correlated with all the examined parameters: body mass index (BMI), waist circumference (WC), hip circumference (HC), waist to hip ratio (WHtR), visceral adiposity index (VAI), LAP and TyG index. Serum kallistatin and afamin concentrations are associated with the anthropometric parameters related to being overweight and to obesity, especially to those describing the visceral distribution of adipose tissue and metabolic disorders related to excessive fatness.https://www.mdpi.com/2077-0383/10/24/5792kallistatinafamincardiovascular diseasesoverweightobesity |
| spellingShingle | Grzegorz Józef Nowicki Barbara Ślusarska Maciej Polak Katarzyna Naylor Tomasz Kocki Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction Journal of Clinical Medicine kallistatin afamin cardiovascular diseases overweight obesity |
| title | Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction |
| title_full | Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction |
| title_fullStr | Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction |
| title_full_unstemmed | Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction |
| title_short | Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction |
| title_sort | relationship between serum kallistatin and afamin and anthropometric factors associated with obesity and of being overweight in patients after myocardial infarction and without myocardial infarction |
| topic | kallistatin afamin cardiovascular diseases overweight obesity |
| url | https://www.mdpi.com/2077-0383/10/24/5792 |
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