The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction
Objective: To evaluate the associations among levels of vitamins A, E, D, and B6 in follicular fluid embryo morphokinetics and quality, and clinical pregnancy rates. Study Design: A total of 58 patients with unexplained infertility admitted to the in vitro fertilisation (IVF) centre of Izmir Medica...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Medical Network
2019-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/860 |
| _version_ | 1828020473310478336 |
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| author | Funda Gode Suleyman Akarsu Zeliha Gunnur Dikmen Burcu Tamer Ahmet Zeki Isik |
| author_facet | Funda Gode Suleyman Akarsu Zeliha Gunnur Dikmen Burcu Tamer Ahmet Zeki Isik |
| author_sort | Funda Gode |
| collection | DOAJ |
| description | Objective: To evaluate the associations among levels of vitamins A, E, D, and B6 in follicular fluid embryo morphokinetics and quality, and clinical pregnancy rates.
Study Design: A total of 58 patients with unexplained infertility admitted to the in vitro fertilisation (IVF) centre of Izmir Medical Park Hospital were included in this prospective clinical study. For each patient, vitamin levels were assayed using high-performance liquid chromatography. After intracytoplasmic sperm injection, for each oocyte, the relationships between each vitamin and subsequent embryo quality, embryo morphokinetics, and clinical pregnancy rates were investigated. Embryos were classified as grade A, B, C, or D according to morphokinetic parameters using t5-t2 and t5-t3 (cc3).
Results: There was no significant correlation between embryo morphokinetic parameters (tpnf, t2, t3, t4, t5, t6, t7 and t8) and follicular fluid vitamin (A, B6, D and E) levels (p>0.05). There was a significant positive correlation between t5optimal and follicular fluid vitamin A levels (p<0.05). There was a significant positive correlation between cc2optimal and follicular fluid vitamin B6 levels (p<0.05). Levels of vitamins A and B6 were significantly higher in grade A and B embryos than in grade C and D embryos. There were no significant relationships between vitamins E or D and embryo quality or between any vitamin and clinical pregnancy rates.
Conclusion: High levels of vitamins A and B6 in follicular fluid are significantly associated with high-quality embryos and optimal morphokinetics. However, none of the vitamins considered showed a significant relationship with clinical pregnancy rates. |
| first_indexed | 2024-04-10T11:39:07Z |
| format | Article |
| id | doaj.art-d6107fa3a2954eca910135310ea438e7 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T11:39:07Z |
| publishDate | 2019-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-d6107fa3a2954eca910135310ea438e72023-02-15T16:17:37ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512019-08-01252899510.21613/GORM.2018.860661The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted ReproductionFunda Gode0Suleyman Akarsu1Zeliha Gunnur Dikmen2Burcu TamerAhmet Zeki IsikBahçeşehir UniversityYukses Ihtisas UniversityHacettepe UniversityObjective: To evaluate the associations among levels of vitamins A, E, D, and B6 in follicular fluid embryo morphokinetics and quality, and clinical pregnancy rates. Study Design: A total of 58 patients with unexplained infertility admitted to the in vitro fertilisation (IVF) centre of Izmir Medical Park Hospital were included in this prospective clinical study. For each patient, vitamin levels were assayed using high-performance liquid chromatography. After intracytoplasmic sperm injection, for each oocyte, the relationships between each vitamin and subsequent embryo quality, embryo morphokinetics, and clinical pregnancy rates were investigated. Embryos were classified as grade A, B, C, or D according to morphokinetic parameters using t5-t2 and t5-t3 (cc3). Results: There was no significant correlation between embryo morphokinetic parameters (tpnf, t2, t3, t4, t5, t6, t7 and t8) and follicular fluid vitamin (A, B6, D and E) levels (p>0.05). There was a significant positive correlation between t5optimal and follicular fluid vitamin A levels (p<0.05). There was a significant positive correlation between cc2optimal and follicular fluid vitamin B6 levels (p<0.05). Levels of vitamins A and B6 were significantly higher in grade A and B embryos than in grade C and D embryos. There were no significant relationships between vitamins E or D and embryo quality or between any vitamin and clinical pregnancy rates. Conclusion: High levels of vitamins A and B6 in follicular fluid are significantly associated with high-quality embryos and optimal morphokinetics. However, none of the vitamins considered showed a significant relationship with clinical pregnancy rates.http://gorm.com.tr/index.php/GORM/article/view/860keywords: vitamin a, vitamin d, vitamin e, vitamin b6, embryomorphokinetics |
| spellingShingle | Funda Gode Suleyman Akarsu Zeliha Gunnur Dikmen Burcu Tamer Ahmet Zeki Isik The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction Gynecology Obstetrics & Reproductive Medicine keywords: vitamin a, vitamin d, vitamin e, vitamin b6, embryomorphokinetics |
| title | The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction |
| title_full | The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction |
| title_fullStr | The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction |
| title_full_unstemmed | The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction |
| title_short | The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction |
| title_sort | effect follicular fluid vitamin a e d and b6 on embryo morphokinetics and pregnancy rates in patients receiving assisted reproduction |
| topic | keywords: vitamin a, vitamin d, vitamin e, vitamin b6, embryomorphokinetics |
| url | http://gorm.com.tr/index.php/GORM/article/view/860 |
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