Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)

Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)

We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain. We thus propose to interfere with the Wnt/β-Catenin signaling pathway and downstream pathways by intraperitoneal injection of PBS buffer (PBS),...

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Bibliographic Details
Main Authors: Xiaobo Yan, Simiao Pan, Tao Li, Weibin Huang, Menglong Zhou, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Aquaculture Reports
Subjects:
Squalene
TWS119
IWR-1
Wnt/β-Catenin
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S235251342300323X

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