Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study
Abstract Blood transfusions from convalescent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected patients could be used to treat patients with severe infections or immunocompromised patients. However, it is necessary to select the optimal donors to maximize the utilization of reso...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-56462-y |
| _version_ | 1797259382941024256 |
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| author | Donglin Tan Xinman Du Jingyun Tang Humin Liu Meng Li Jianxun Kang Xiaochun Li Ying Li Yue Luo Qing Wang Xiaobo Gu Zonghan Zhao Xuemei Fu Xue Chen |
| author_facet | Donglin Tan Xinman Du Jingyun Tang Humin Liu Meng Li Jianxun Kang Xiaochun Li Ying Li Yue Luo Qing Wang Xiaobo Gu Zonghan Zhao Xuemei Fu Xue Chen |
| author_sort | Donglin Tan |
| collection | DOAJ |
| description | Abstract Blood transfusions from convalescent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected patients could be used to treat patients with severe infections or immunocompromised patients. However, it is necessary to select the optimal donors to maximize the utilization of resources. In this study, we investigated the associations among body mass index (BMI), tobacco smoking, exercise frequency and duration, and alcohol consumption with the SARS-CoV-2 immunoglobulin-G (IgG) antibody titer levels with in the Chinese convalescent blood donor population. Here we show that BMI, smoking habits, and exercise frequency appear to be predictive factors for IgG levels in convalescent male blood donors. However, these variables were not observed as predictive of IgG levels in female convalescent blood donors. The findings could be used to optimize the screening for potential blood donors to treat immunocompromised or severely ill COVID-19 patients. |
| first_indexed | 2024-04-24T23:08:33Z |
| format | Article |
| id | doaj.art-d6177e77c7b441149ead013a9b232627 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:08:33Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d6177e77c7b441149ead013a9b2326272024-03-17T12:23:01ZengNature PortfolioScientific Reports2045-23222024-03-011411810.1038/s41598-024-56462-yFactors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional studyDonglin Tan0Xinman Du1Jingyun Tang2Humin Liu3Meng Li4Jianxun Kang5Xiaochun Li6Ying Li7Yue Luo8Qing Wang9Xiaobo Gu10Zonghan Zhao11Xuemei Fu12Xue Chen13Department of Blood Processing, Chengdu Blood CenterBlood Research Laboratory, Chengdu Blood CenterBlood Research Laboratory, Chengdu Blood CenterDepartment of Blood Testing, Chengdu Blood CenterBlood Research Laboratory, Chengdu Blood CenterBlood Research Laboratory, Chengdu Blood CenterDepartment of Blood Processing, Chengdu Blood CenterDepartment of Blood Testing, Chengdu Blood CenterBlood Research Laboratory, Chengdu Blood CenterDepartment of Blood Collection, Chengdu Blood CenterDepartment of Blood Collection, Chengdu Blood CenterDepartment of Blood Collection, Chengdu Blood CenterDepartment of Blood Processing, Chengdu Blood CenterDepartment of Blood Processing, Chengdu Blood CenterAbstract Blood transfusions from convalescent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected patients could be used to treat patients with severe infections or immunocompromised patients. However, it is necessary to select the optimal donors to maximize the utilization of resources. In this study, we investigated the associations among body mass index (BMI), tobacco smoking, exercise frequency and duration, and alcohol consumption with the SARS-CoV-2 immunoglobulin-G (IgG) antibody titer levels with in the Chinese convalescent blood donor population. Here we show that BMI, smoking habits, and exercise frequency appear to be predictive factors for IgG levels in convalescent male blood donors. However, these variables were not observed as predictive of IgG levels in female convalescent blood donors. The findings could be used to optimize the screening for potential blood donors to treat immunocompromised or severely ill COVID-19 patients.https://doi.org/10.1038/s41598-024-56462-y |
| spellingShingle | Donglin Tan Xinman Du Jingyun Tang Humin Liu Meng Li Jianxun Kang Xiaochun Li Ying Li Yue Luo Qing Wang Xiaobo Gu Zonghan Zhao Xuemei Fu Xue Chen Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study Scientific Reports |
| title | Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study |
| title_full | Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study |
| title_fullStr | Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study |
| title_full_unstemmed | Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study |
| title_short | Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study |
| title_sort | factors associated with the sars cov 2 immunoglobulin g titer levels in convalescent whole blood donors a chinese cross sectional study |
| url | https://doi.org/10.1038/s41598-024-56462-y |
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