IgG subclasses and allotypes: from structure to effector functions

IgG subclasses and allotypes: from structure to effector functions

Of the five immunoglobulin isotypes, Immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3 and IgG4 which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both I...

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Bibliographic Details
Main Authors: Gestur eVidarsson, Gillian eDekkers, Theo eRispens
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Immunology
Subjects:
Glycosylation
Immunoglobulin G
Polymorphism, Genetic
IgG
Fc receptors
Neonatal Fc Receptor (FcRn)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00520/full

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