Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warrantedResearch in context

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warrantedResearch in context

Summary: Background: SARS-CoV-2-neutralizing antibodies (nABs) showed great promise in the early phases of the COVID-19 pandemic. The emergence of resistant strains, however, quickly rendered the majority of clinically approved nABs ineffective. This underscored the imperative to develop nAB cockta...

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Bibliographic Details
Main Authors: Delphine Diana Acar, Wojciech Witkowski, Magdalena Wejda, Ruifang Wei, Tim Desmet, Bert Schepens, Sieglinde De Cae, Koen Sedeyn, Hannah Eeckhaut, Daria Fijalkowska, Kenny Roose, Sandrine Vanmarcke, Anne Poupon, Dirk Jochmans, Xin Zhang, Rana Abdelnabi, Caroline S. Foo, Birgit Weynand, Dirk Reiter, Nico Callewaert, Han Remaut, Johan Neyts, Xavier Saelens, Sarah Gerlo, Linos Vandekerckhove
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
Neutralizing antibody
In silico prediction
Epitope mapping
Covid-19
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423005261

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