A STAT3-based gene signature stratifies glioma patients for targeted therapy
STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11614-x |
| _version_ | 1818842085461065728 |
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| author | Melanie Si Yan Tan Edwin Sandanaraj Yuk Kien Chong See Wee Lim Lynnette Wei Hsien Koh Wai Hoe Ng Nguan Soon Tan Patrick Tan Beng Ti Ang Carol Tang |
| author_facet | Melanie Si Yan Tan Edwin Sandanaraj Yuk Kien Chong See Wee Lim Lynnette Wei Hsien Koh Wai Hoe Ng Nguan Soon Tan Patrick Tan Beng Ti Ang Carol Tang |
| author_sort | Melanie Si Yan Tan |
| collection | DOAJ |
| description | STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy. |
| first_indexed | 2024-12-19T04:36:22Z |
| format | Article |
| id | doaj.art-d61c46f20a3c44179f855b1383771751 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:36:22Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d61c46f20a3c44179f855b13837717512022-12-21T20:35:44ZengNature PortfolioNature Communications2041-17232019-08-0110111510.1038/s41467-019-11614-xA STAT3-based gene signature stratifies glioma patients for targeted therapyMelanie Si Yan Tan0Edwin Sandanaraj1Yuk Kien Chong2See Wee Lim3Lynnette Wei Hsien Koh4Wai Hoe Ng5Nguan Soon Tan6Patrick Tan7Beng Ti Ang8Carol Tang9Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience InstituteNeuro-Oncology Research Laboratory, Department of Research, National Neuroscience InstituteNeuro-Oncology Research Laboratory, Department of Research, National Neuroscience InstituteNeuro-Oncology Research Laboratory, Department of Research, National Neuroscience InstituteNeuro-Oncology Research Laboratory, Department of Research, National Neuroscience InstituteDepartment of Neurosurgery, National Neuroscience InstituteSchool of Biological Sciences, Nanyang Technological UniversityDuke-National University of Singapore Medical SchoolSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR)Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience InstituteSTAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.https://doi.org/10.1038/s41467-019-11614-x |
| spellingShingle | Melanie Si Yan Tan Edwin Sandanaraj Yuk Kien Chong See Wee Lim Lynnette Wei Hsien Koh Wai Hoe Ng Nguan Soon Tan Patrick Tan Beng Ti Ang Carol Tang A STAT3-based gene signature stratifies glioma patients for targeted therapy Nature Communications |
| title | A STAT3-based gene signature stratifies glioma patients for targeted therapy |
| title_full | A STAT3-based gene signature stratifies glioma patients for targeted therapy |
| title_fullStr | A STAT3-based gene signature stratifies glioma patients for targeted therapy |
| title_full_unstemmed | A STAT3-based gene signature stratifies glioma patients for targeted therapy |
| title_short | A STAT3-based gene signature stratifies glioma patients for targeted therapy |
| title_sort | stat3 based gene signature stratifies glioma patients for targeted therapy |
| url | https://doi.org/10.1038/s41467-019-11614-x |
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