Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report
Abstract Background Recurrence of multiple myeloma is among the most challenging issues for patients and treating physicians reported after autologous stem cell transplantation. However, extramedullary involvement after chemotherapy and transplantation has been rarely reported, especially as pleural...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-03765-9 |
| _version_ | 1811165962107355136 |
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| author | Alireza Rezvani Reza Shahriarirad Mohammad Javad Fallahi Ali Zeighami |
| author_facet | Alireza Rezvani Reza Shahriarirad Mohammad Javad Fallahi Ali Zeighami |
| author_sort | Alireza Rezvani |
| collection | DOAJ |
| description | Abstract Background Recurrence of multiple myeloma is among the most challenging issues for patients and treating physicians reported after autologous stem cell transplantation. However, extramedullary involvement after chemotherapy and transplantation has been rarely reported, especially as pleural manifestations. Protein electrophoresis indicated immunoglobulin A monoclonal kappa plasma cell neoplasm in our case. Case presentation A 48-year-old middle-eastern man was referred to our clinic with cough, dyspnea, fever, and left side pleural effusion. A year after chemotherapy and autologous bone marrow transplantation, the patient presented with features in favor of pleural relapse, without bone marrow involvement. Protein electrophoresis demonstrated immunoglobulin A monoclonal kappa plasma cell neoplasm in our case. The patient was effectively treated with dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, and etoposide with no notable adverse effects. Conclusion Physicians should be aware of various presentations of multiple myeloma relapse, especially in autologous stem cell transplantation patients. Atypical and unique presentations such as the pleural involvement warrant further reporting of evidence to provide early management and treatment options. |
| first_indexed | 2024-04-10T15:44:40Z |
| format | Article |
| id | doaj.art-d61cf02da59d40069243df8b4d082c83 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-10T15:44:40Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-d61cf02da59d40069243df8b4d082c832023-02-12T12:13:25ZengBMCJournal of Medical Case Reports1752-19472023-02-011711710.1186/s13256-023-03765-9Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case reportAlireza Rezvani0Reza Shahriarirad1Mohammad Javad Fallahi2Ali Zeighami3Bone Marrow Transplantation Center, Nemazi Hospital, Shiraz University of Medical SciencesThoracic and Vascular Surgery Research Center, Shiraz University of Medical ScienceDepartment of Internal Medicine, Nemazee Hospital, Shiraz University of Medical SciencesThoracic and Vascular Surgery Research Center, Shiraz University of Medical ScienceAbstract Background Recurrence of multiple myeloma is among the most challenging issues for patients and treating physicians reported after autologous stem cell transplantation. However, extramedullary involvement after chemotherapy and transplantation has been rarely reported, especially as pleural manifestations. Protein electrophoresis indicated immunoglobulin A monoclonal kappa plasma cell neoplasm in our case. Case presentation A 48-year-old middle-eastern man was referred to our clinic with cough, dyspnea, fever, and left side pleural effusion. A year after chemotherapy and autologous bone marrow transplantation, the patient presented with features in favor of pleural relapse, without bone marrow involvement. Protein electrophoresis demonstrated immunoglobulin A monoclonal kappa plasma cell neoplasm in our case. The patient was effectively treated with dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, and etoposide with no notable adverse effects. Conclusion Physicians should be aware of various presentations of multiple myeloma relapse, especially in autologous stem cell transplantation patients. Atypical and unique presentations such as the pleural involvement warrant further reporting of evidence to provide early management and treatment options.https://doi.org/10.1186/s13256-023-03765-9Multiple myelomaBone marrow transplantationPleural effusionRecurrenceCase report |
| spellingShingle | Alireza Rezvani Reza Shahriarirad Mohammad Javad Fallahi Ali Zeighami Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report Journal of Medical Case Reports Multiple myeloma Bone marrow transplantation Pleural effusion Recurrence Case report |
| title | Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report |
| title_full | Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report |
| title_fullStr | Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report |
| title_full_unstemmed | Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report |
| title_short | Extramedullary relapse of Immunoglobulin A-kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant: a case report |
| title_sort | extramedullary relapse of immunoglobulin a kappa myeloma manifesting as plasmacytoma of the pleura without bone marrow involvement and following autologous bone marrow transplant a case report |
| topic | Multiple myeloma Bone marrow transplantation Pleural effusion Recurrence Case report |
| url | https://doi.org/10.1186/s13256-023-03765-9 |
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