Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
Naeti Suksomboon,1 Nalinee Poolsup,2 Htoo Darli Ko Ko1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand Objective: To perform a systematic review and meta-analysis of rando...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/effect-of-vitamin-k-supplementation-on-insulin-sensitivity-a-meta-anal-peer-reviewed-article-DMSO |
| _version_ | 1797935572620148736 |
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| author | Suksomboon N Poolsup N Darli Ko Ko H |
| author_facet | Suksomboon N Poolsup N Darli Ko Ko H |
| author_sort | Suksomboon N |
| collection | DOAJ |
| description | Naeti Suksomboon,1 Nalinee Poolsup,2 Htoo Darli Ko Ko1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand Objective: To perform a systematic review and meta-analysis of randomized, placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity.Data sources: MEDLINE, the Cochrane Library, CINAHL, Web of Science, Scopus, clinicaltrials.gov, and clinicaltrialresults.org were searched up to January 2017. Reference lists of related papers were also scanned.Study selection: Randomized controlled trials were selected if they compared vitamin K supplementation with placebo or no treatment and reported homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, or interleukin-6 levels.Data extraction: Data extraction and study quality assessment were performed independently by two investigators using a standardized data extraction form. Any inconsistencies were resolved by a third reviewer. Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.Results: A total of eight trials involving 1,077 participants met the inclusion criteria. A wide variety of participants were enrolled, including older men, postmenopausal women, prediabetic premenopausal women, and participants with a history of diabetes, hypertension, or vascular disease. Vitamin K1 and vitamin K2 (MK-4 and MK-7 subtypes) were assessed. Supplementation period ranged from 4 weeks to 3 years. Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, and interleukin-6 levels.Conclusion: Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity. Keywords: vitamin K, insulin resistance, meta-analysis, systematic review |
| first_indexed | 2024-04-10T18:16:19Z |
| format | Article |
| id | doaj.art-d61dc386f54c4e5580ff116b4566a9b8 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:16:19Z |
| publishDate | 2017-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-d61dc386f54c4e5580ff116b4566a9b82023-02-02T08:51:27ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072017-05-01Volume 1016917732629Effect of vitamin K supplementation on insulin sensitivity: a meta-analysisSuksomboon NPoolsup NDarli Ko Ko HNaeti Suksomboon,1 Nalinee Poolsup,2 Htoo Darli Ko Ko1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand Objective: To perform a systematic review and meta-analysis of randomized, placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity.Data sources: MEDLINE, the Cochrane Library, CINAHL, Web of Science, Scopus, clinicaltrials.gov, and clinicaltrialresults.org were searched up to January 2017. Reference lists of related papers were also scanned.Study selection: Randomized controlled trials were selected if they compared vitamin K supplementation with placebo or no treatment and reported homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, or interleukin-6 levels.Data extraction: Data extraction and study quality assessment were performed independently by two investigators using a standardized data extraction form. Any inconsistencies were resolved by a third reviewer. Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.Results: A total of eight trials involving 1,077 participants met the inclusion criteria. A wide variety of participants were enrolled, including older men, postmenopausal women, prediabetic premenopausal women, and participants with a history of diabetes, hypertension, or vascular disease. Vitamin K1 and vitamin K2 (MK-4 and MK-7 subtypes) were assessed. Supplementation period ranged from 4 weeks to 3 years. Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, and interleukin-6 levels.Conclusion: Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity. Keywords: vitamin K, insulin resistance, meta-analysis, systematic reviewhttps://www.dovepress.com/effect-of-vitamin-k-supplementation-on-insulin-sensitivity-a-meta-anal-peer-reviewed-article-DMSOvitamin Kinsulin resistancemeta-analysissystematic review |
| spellingShingle | Suksomboon N Poolsup N Darli Ko Ko H Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis Diabetes, Metabolic Syndrome and Obesity vitamin K insulin resistance meta-analysis systematic review |
| title | Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis |
| title_full | Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis |
| title_fullStr | Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis |
| title_full_unstemmed | Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis |
| title_short | Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis |
| title_sort | effect of vitamin k supplementation on insulin sensitivity a meta analysis |
| topic | vitamin K insulin resistance meta-analysis systematic review |
| url | https://www.dovepress.com/effect-of-vitamin-k-supplementation-on-insulin-sensitivity-a-meta-anal-peer-reviewed-article-DMSO |
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