Epigenetic Regulation Mediated by Sphingolipids in Cancer
Epigenetic changes are heritable modifications that do not directly affect the DNA sequence. In cancer cells, the maintenance of a stable epigenetic profile can be crucial to support survival and proliferation, and said profile can differ significantly from that of healthy cells. The epigenetic prof...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5294 |
| _version_ | 1797611338906730496 |
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| author | Nicolò Bozzini Sofia Avnet Nicola Baldini Margherita Cortini |
| author_facet | Nicolò Bozzini Sofia Avnet Nicola Baldini Margherita Cortini |
| author_sort | Nicolò Bozzini |
| collection | DOAJ |
| description | Epigenetic changes are heritable modifications that do not directly affect the DNA sequence. In cancer cells, the maintenance of a stable epigenetic profile can be crucial to support survival and proliferation, and said profile can differ significantly from that of healthy cells. The epigenetic profile of a cancer cell can be modulated by several factors, including metabolites. Recently, sphingolipids have emerged as novel modulators of epigenetic changes. Ceramide and sphingosine 1-phosphate have become well known in cancer due to activating anti-tumour and pro-tumour signalling pathways, respectively, and they have recently been shown to also induce several epigenetic modifications connected to cancer growth. Additionally, acellular factors in the tumour microenvironment, such as hypoxia and acidosis, are now recognised as crucial in promoting aggressiveness through several mechanisms, including epigenetic modifications. Here, we review the existing literature on sphingolipids, cancer, and epigenetic changes, with a focus on the interaction between these elements and components of the chemical tumour microenvironment. |
| first_indexed | 2024-03-11T06:27:31Z |
| format | Article |
| id | doaj.art-d61e821c744d47c288c93c326d9ca429 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:27:31Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d61e821c744d47c288c93c326d9ca4292023-11-17T11:31:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246529410.3390/ijms24065294Epigenetic Regulation Mediated by Sphingolipids in CancerNicolò Bozzini0Sofia Avnet1Nicola Baldini2Margherita Cortini3Biomedical Science and Technologies and Nanobiotecnologiy Lab., IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyBiomedical Science and Technologies and Nanobiotecnologiy Lab., IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyBiomedical Science and Technologies and Nanobiotecnologiy Lab., IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyEpigenetic changes are heritable modifications that do not directly affect the DNA sequence. In cancer cells, the maintenance of a stable epigenetic profile can be crucial to support survival and proliferation, and said profile can differ significantly from that of healthy cells. The epigenetic profile of a cancer cell can be modulated by several factors, including metabolites. Recently, sphingolipids have emerged as novel modulators of epigenetic changes. Ceramide and sphingosine 1-phosphate have become well known in cancer due to activating anti-tumour and pro-tumour signalling pathways, respectively, and they have recently been shown to also induce several epigenetic modifications connected to cancer growth. Additionally, acellular factors in the tumour microenvironment, such as hypoxia and acidosis, are now recognised as crucial in promoting aggressiveness through several mechanisms, including epigenetic modifications. Here, we review the existing literature on sphingolipids, cancer, and epigenetic changes, with a focus on the interaction between these elements and components of the chemical tumour microenvironment.https://www.mdpi.com/1422-0067/24/6/5294epigeneticscancersphingolipidstumour microenvironmenthypoxiaacidosis |
| spellingShingle | Nicolò Bozzini Sofia Avnet Nicola Baldini Margherita Cortini Epigenetic Regulation Mediated by Sphingolipids in Cancer International Journal of Molecular Sciences epigenetics cancer sphingolipids tumour microenvironment hypoxia acidosis |
| title | Epigenetic Regulation Mediated by Sphingolipids in Cancer |
| title_full | Epigenetic Regulation Mediated by Sphingolipids in Cancer |
| title_fullStr | Epigenetic Regulation Mediated by Sphingolipids in Cancer |
| title_full_unstemmed | Epigenetic Regulation Mediated by Sphingolipids in Cancer |
| title_short | Epigenetic Regulation Mediated by Sphingolipids in Cancer |
| title_sort | epigenetic regulation mediated by sphingolipids in cancer |
| topic | epigenetics cancer sphingolipids tumour microenvironment hypoxia acidosis |
| url | https://www.mdpi.com/1422-0067/24/6/5294 |
| work_keys_str_mv | AT nicolobozzini epigeneticregulationmediatedbysphingolipidsincancer AT sofiaavnet epigeneticregulationmediatedbysphingolipidsincancer AT nicolabaldini epigeneticregulationmediatedbysphingolipidsincancer AT margheritacortini epigeneticregulationmediatedbysphingolipidsincancer |