Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

The stabilisation of HIF-α is central to the transcriptional response of animals to hypoxia, regulating the expression of hundreds of genes including those involved in angiogenesis, metabolism and metastasis. HIF-α is degraded under normoxic conditions by proline hydroxylation, which allows for reco...

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Bibliographic Details
Main Authors: Cameron E Snell, Helen Turley, Alan McIntyre, Demin Li, Massimo Masiero, Christopher J Schofield, Kevin C Gatter, Adrian L Harris, Francesco Pezzella
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24563687/?tool=EBI

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