Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade
Mycobacterium tuberculosis (MTB) infection and lung malignancies are both important causes of pericardial effusion (PE), particularly in developing nations such as South Africa. They are each associated with significant morbidity and mortality and pose several public health challenges for the region...
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| Format: | Article |
| Language: | English |
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AOSIS
2023-02-01
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| Series: | South African Journal of Oncology |
| Subjects: | |
| Online Access: | https://sajo.org.za/index.php/sajo/article/view/255 |
| _version_ | 1811161314298429440 |
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| author | Kishendree Naicker Sameera Dalvie Qonita Said-Hartley Mpiko Ntsekhe |
| author_facet | Kishendree Naicker Sameera Dalvie Qonita Said-Hartley Mpiko Ntsekhe |
| author_sort | Kishendree Naicker |
| collection | DOAJ |
| description | Mycobacterium tuberculosis (MTB) infection and lung malignancies are both important causes of pericardial effusion (PE), particularly in developing nations such as South Africa. They are each associated with significant morbidity and mortality and pose several public health challenges for the region. This case study discussed a 58-year-old man who presented acutely with a large PE complicated by cardiac tamponade. Pericardial fluid analysis was positive for TB and further cytopathological evaluation revealed metastatic lung adenocarcinoma. Dual diagnoses are rare; however, considering the rising incidences of lung cancer and its predisposition for infectious diseases, this may be under-reported in TB endemic regions. This case highlighted the importance of considering other causes of PE that may aggravate presentation, leading to life-threatening cardiac tamponade. Further research is needed to understand the impact of rising cancer incidences and ongoing burden of infectious diseases in sub-Saharan Africa.
Contribution: The insights of this case study include the paucity of data surrounding diagnosis and treatment of lung cancer in non-smokers available for South Africa. The current data that are available is for the developed world only. Some evidence incidence might be related to exposure of biofuels, which has significance for our local population and requires more exact research. |
| first_indexed | 2024-04-10T06:13:19Z |
| format | Article |
| id | doaj.art-d61f86ac415141568b3b4140f861f374 |
| institution | Directory Open Access Journal |
| issn | 2518-8704 2523-0646 |
| language | English |
| last_indexed | 2024-04-10T06:13:19Z |
| publishDate | 2023-02-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Oncology |
| spelling | doaj.art-d61f86ac415141568b3b4140f861f3742023-03-02T11:57:50ZengAOSISSouth African Journal of Oncology2518-87042523-06462023-02-0170e1e510.4102/sajo.v7i0.255106Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponadeKishendree Naicker0Sameera Dalvie1Qonita Said-Hartley2Mpiko Ntsekhe3Division of Cardiology, Faculty of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa; and, Department of Radiation Oncology, Faculty of Radiation Medicine, University of Cape Town, Groote Schuur Hospital, Cape TownDepartment of Radiation Oncology, Faculty of Radiation Medicine, University of Cape Town, Groote Schuur Hospital, Cape TownDepartment of Radiology, Faculty of Radiation Medicine, University of Cape Town, Groote Schuur Hospital, Cape TownDivision of Cardiology, Faculty of Medicine, University of Cape Town, Groote Schuur Hospital, Cape TownMycobacterium tuberculosis (MTB) infection and lung malignancies are both important causes of pericardial effusion (PE), particularly in developing nations such as South Africa. They are each associated with significant morbidity and mortality and pose several public health challenges for the region. This case study discussed a 58-year-old man who presented acutely with a large PE complicated by cardiac tamponade. Pericardial fluid analysis was positive for TB and further cytopathological evaluation revealed metastatic lung adenocarcinoma. Dual diagnoses are rare; however, considering the rising incidences of lung cancer and its predisposition for infectious diseases, this may be under-reported in TB endemic regions. This case highlighted the importance of considering other causes of PE that may aggravate presentation, leading to life-threatening cardiac tamponade. Further research is needed to understand the impact of rising cancer incidences and ongoing burden of infectious diseases in sub-Saharan Africa. Contribution: The insights of this case study include the paucity of data surrounding diagnosis and treatment of lung cancer in non-smokers available for South Africa. The current data that are available is for the developed world only. Some evidence incidence might be related to exposure of biofuels, which has significance for our local population and requires more exact research.https://sajo.org.za/index.php/sajo/article/view/255pericardial effusion, cardiac tamponade, tuberculosis, effusive pericarditis, lung carcinoma |
| spellingShingle | Kishendree Naicker Sameera Dalvie Qonita Said-Hartley Mpiko Ntsekhe Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade South African Journal of Oncology pericardial effusion, cardiac tamponade, tuberculosis, effusive pericarditis, lung carcinoma |
| title | Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade |
| title_full | Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade |
| title_fullStr | Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade |
| title_full_unstemmed | Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade |
| title_short | Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade |
| title_sort | concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade |
| topic | pericardial effusion, cardiac tamponade, tuberculosis, effusive pericarditis, lung carcinoma |
| url | https://sajo.org.za/index.php/sajo/article/view/255 |
| work_keys_str_mv | AT kishendreenaicker concurrenttuberculouspericarditisandlungadenocarcinomapresentingwithcardiactamponade AT sameeradalvie concurrenttuberculouspericarditisandlungadenocarcinomapresentingwithcardiactamponade AT qonitasaidhartley concurrenttuberculouspericarditisandlungadenocarcinomapresentingwithcardiactamponade AT mpikontsekhe concurrenttuberculouspericarditisandlungadenocarcinomapresentingwithcardiactamponade |