Hydrogels for Exosome Delivery in Biomedical Applications
Hydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological and biomedical applications, such as for drug delivery, tissue engineering, and models for medical studies, have been made. Due to their similarity in physiological structu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/6/328 |
| _version_ | 1797487268158504960 |
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| author | Yaxin Xie Qiuyue Guan Jiusi Guo Yilin Chen Yijia Yin Xianglong Han |
| author_facet | Yaxin Xie Qiuyue Guan Jiusi Guo Yilin Chen Yijia Yin Xianglong Han |
| author_sort | Yaxin Xie |
| collection | DOAJ |
| description | Hydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological and biomedical applications, such as for drug delivery, tissue engineering, and models for medical studies, have been made. Due to their similarity in physiological structure, hydrogels are highly compatible with extracellular matrices and biological tissues and can be used as both carriers and matrices to encapsulate cellular secretions. As small extracellular vesicles secreted by nearly all mammalian cells to mediate cell–cell interactions, exosomes play very important roles in therapeutic approaches and disease diagnosis. To maintain their biological activity and achieve controlled release, a strategy that embeds exosomes in hydrogels as a composite system has been focused on in recent studies. Therefore, this review aims to provide a thorough overview of the use of composite hydrogels for embedding exosomes in medical applications, including the resources for making hydrogels and the properties of hydrogels, and strategies for their combination with exosomes. |
| first_indexed | 2024-03-09T23:45:13Z |
| format | Article |
| id | doaj.art-d62689fa2c484612a29b859c5a82a8ac |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T23:45:13Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-d62689fa2c484612a29b859c5a82a8ac2023-11-23T16:44:57ZengMDPI AGGels2310-28612022-05-018632810.3390/gels8060328Hydrogels for Exosome Delivery in Biomedical ApplicationsYaxin Xie0Qiuyue Guan1Jiusi Guo2Yilin Chen3Yijia Yin4Xianglong Han5State Key Laboratory of Oral Diseases, Department of Orthodontics, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Geriatrics, People’s Hospital of Sichuan Province, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, Department of Orthodontics, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, Department of Orthodontics, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, Department of Orthodontics, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, Department of Orthodontics, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaHydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological and biomedical applications, such as for drug delivery, tissue engineering, and models for medical studies, have been made. Due to their similarity in physiological structure, hydrogels are highly compatible with extracellular matrices and biological tissues and can be used as both carriers and matrices to encapsulate cellular secretions. As small extracellular vesicles secreted by nearly all mammalian cells to mediate cell–cell interactions, exosomes play very important roles in therapeutic approaches and disease diagnosis. To maintain their biological activity and achieve controlled release, a strategy that embeds exosomes in hydrogels as a composite system has been focused on in recent studies. Therefore, this review aims to provide a thorough overview of the use of composite hydrogels for embedding exosomes in medical applications, including the resources for making hydrogels and the properties of hydrogels, and strategies for their combination with exosomes.https://www.mdpi.com/2310-2861/8/6/328composite hydrogelexosomebiomedical engineering |
| spellingShingle | Yaxin Xie Qiuyue Guan Jiusi Guo Yilin Chen Yijia Yin Xianglong Han Hydrogels for Exosome Delivery in Biomedical Applications Gels composite hydrogel exosome biomedical engineering |
| title | Hydrogels for Exosome Delivery in Biomedical Applications |
| title_full | Hydrogels for Exosome Delivery in Biomedical Applications |
| title_fullStr | Hydrogels for Exosome Delivery in Biomedical Applications |
| title_full_unstemmed | Hydrogels for Exosome Delivery in Biomedical Applications |
| title_short | Hydrogels for Exosome Delivery in Biomedical Applications |
| title_sort | hydrogels for exosome delivery in biomedical applications |
| topic | composite hydrogel exosome biomedical engineering |
| url | https://www.mdpi.com/2310-2861/8/6/328 |
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