The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review
Dry eye disease (DED) is a common disease, and have an adverse effect the physical, functional, and psychological quality of life. It is a multifactorial disorder characterized by the loss of tear film homeostasis, in which self-perpetuating vicious cycle leads to deterioration of function and infla...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/10/4519 |
| _version_ | 1827692452989894656 |
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| author | Joon-Young Hyon Sang-Beom Han |
| author_facet | Joon-Young Hyon Sang-Beom Han |
| author_sort | Joon-Young Hyon |
| collection | DOAJ |
| description | Dry eye disease (DED) is a common disease, and have an adverse effect the physical, functional, and psychological quality of life. It is a multifactorial disorder characterized by the loss of tear film homeostasis, in which self-perpetuating vicious cycle leads to deterioration of function and inflammation of the lacrimal functional unit. Hence, treatment strategies should be aimed at the interruption of the vicious inflammatory cycle and alleviation of ocular surface inflammation. Anti-inflammatory therapies have been shown to improve the signs and symptoms of the disease. Evidence indicates that polyunsaturated fatty acids (PUFAs) may contribute to reinforcement of innate anti-inflammatory mechanisms, and systemic and topical administration of PUFAs may help modulate ocular surface inflammation. In the present review, the authors will introduce the results of clinical and experimental studies to elucidate the mechanism, efficacy, and safety of systemic and topical supplementation with PUFAs as an alternative therapeutic strategy for DED. This review will also include discussion regarding current perspectives, including evidence-based recommendations and possible side effects of PUFAs supplementation. The review of the literature suggests that PUFAs supplementation can be a viable option for the treatment of DED, although further studies are needed for establishment of treatment guidelines. |
| first_indexed | 2024-03-10T11:23:22Z |
| format | Article |
| id | doaj.art-d62782799e064ae09b8308e955e2d63c |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:23:22Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d62782799e064ae09b8308e955e2d63c2023-11-21T19:54:41ZengMDPI AGApplied Sciences2076-34172021-05-011110451910.3390/app11104519The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature ReviewJoon-Young Hyon0Sang-Beom Han1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Ophthalmology, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon 24289, KoreaDry eye disease (DED) is a common disease, and have an adverse effect the physical, functional, and psychological quality of life. It is a multifactorial disorder characterized by the loss of tear film homeostasis, in which self-perpetuating vicious cycle leads to deterioration of function and inflammation of the lacrimal functional unit. Hence, treatment strategies should be aimed at the interruption of the vicious inflammatory cycle and alleviation of ocular surface inflammation. Anti-inflammatory therapies have been shown to improve the signs and symptoms of the disease. Evidence indicates that polyunsaturated fatty acids (PUFAs) may contribute to reinforcement of innate anti-inflammatory mechanisms, and systemic and topical administration of PUFAs may help modulate ocular surface inflammation. In the present review, the authors will introduce the results of clinical and experimental studies to elucidate the mechanism, efficacy, and safety of systemic and topical supplementation with PUFAs as an alternative therapeutic strategy for DED. This review will also include discussion regarding current perspectives, including evidence-based recommendations and possible side effects of PUFAs supplementation. The review of the literature suggests that PUFAs supplementation can be a viable option for the treatment of DED, although further studies are needed for establishment of treatment guidelines.https://www.mdpi.com/2076-3417/11/10/4519dry eyedry eye diseaseessential fatty acidsocular surfaceomega-3polyunsaturated fatty acids |
| spellingShingle | Joon-Young Hyon Sang-Beom Han The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review Applied Sciences dry eye dry eye disease essential fatty acids ocular surface omega-3 polyunsaturated fatty acids |
| title | The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review |
| title_full | The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review |
| title_fullStr | The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review |
| title_full_unstemmed | The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review |
| title_short | The Protective Effect of Polyunsaturated Fatty Acids against Dry Eye Disease: A Literature Review |
| title_sort | protective effect of polyunsaturated fatty acids against dry eye disease a literature review |
| topic | dry eye dry eye disease essential fatty acids ocular surface omega-3 polyunsaturated fatty acids |
| url | https://www.mdpi.com/2076-3417/11/10/4519 |
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