Polymers Blending as Release Modulating Tool in Drug Delivery
Different polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2021.752813/full |
| _version_ | 1818740891058176000 |
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| author | Parisa Ghasemiyeh Parisa Ghasemiyeh Soliman Mohammadi-Samani Soliman Mohammadi-Samani |
| author_facet | Parisa Ghasemiyeh Parisa Ghasemiyeh Soliman Mohammadi-Samani Soliman Mohammadi-Samani |
| author_sort | Parisa Ghasemiyeh |
| collection | DOAJ |
| description | Different polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to a specific organ or site of action is a complicated task for pharmaceutical scientists. In this regard, polymer blending has been considered as an attractive approach to fabricate novel and unique drug delivery systems with modified physical and/or chemical characteristics. There are three major polymer blending approaches that are used for drug delivery purposes: physical mixtures, core-shell model, and block copolymer model. Each of these types of polymer blends could significantly affect the loading capacities and the kinetics of drug release from the relevant formulations. Drug release from these blended polymers can be tuned through the changes in temperature and pH of the environment, and physiochemical properties of the target organs. Furthermore, the possible molecular interactions among polymers and drug molecules can significantly affect the drug release profile from these blended polymeric micro- and nanocarriers. In this review, first of all, different types of polymers and their various applications in biomedical sciences have been discussed and smart or stimuli responsive polymers are introduced and categorized based on their nature. Then, the purpose of polymer blending in drug delivery systems has been discussed. Different types of polymer blends including physical mixtures, core-shell polymeric carriers, and block copolymers have been summarized with focus on the effect of polymer blending on encapsulated drug release profiles. Finally, the consequence of each blending approach on drug release profile and kinetics of drug release have been mentioned in tabular format. |
| first_indexed | 2024-12-18T01:47:55Z |
| format | Article |
| id | doaj.art-d6290176fe834fad8f42410205e508e9 |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-18T01:47:55Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-d6290176fe834fad8f42410205e508e92022-12-21T21:25:08ZengFrontiers Media S.A.Frontiers in Materials2296-80162021-11-01810.3389/fmats.2021.752813752813Polymers Blending as Release Modulating Tool in Drug DeliveryParisa Ghasemiyeh0Parisa Ghasemiyeh1Soliman Mohammadi-Samani2Soliman Mohammadi-Samani3Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranPharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranPharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDifferent polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to a specific organ or site of action is a complicated task for pharmaceutical scientists. In this regard, polymer blending has been considered as an attractive approach to fabricate novel and unique drug delivery systems with modified physical and/or chemical characteristics. There are three major polymer blending approaches that are used for drug delivery purposes: physical mixtures, core-shell model, and block copolymer model. Each of these types of polymer blends could significantly affect the loading capacities and the kinetics of drug release from the relevant formulations. Drug release from these blended polymers can be tuned through the changes in temperature and pH of the environment, and physiochemical properties of the target organs. Furthermore, the possible molecular interactions among polymers and drug molecules can significantly affect the drug release profile from these blended polymeric micro- and nanocarriers. In this review, first of all, different types of polymers and their various applications in biomedical sciences have been discussed and smart or stimuli responsive polymers are introduced and categorized based on their nature. Then, the purpose of polymer blending in drug delivery systems has been discussed. Different types of polymer blends including physical mixtures, core-shell polymeric carriers, and block copolymers have been summarized with focus on the effect of polymer blending on encapsulated drug release profiles. Finally, the consequence of each blending approach on drug release profile and kinetics of drug release have been mentioned in tabular format.https://www.frontiersin.org/articles/10.3389/fmats.2021.752813/fullpolymers blendingcore-shell polymeric carriersblock copolymersphysical mixturesrelease profiledrug delivery |
| spellingShingle | Parisa Ghasemiyeh Parisa Ghasemiyeh Soliman Mohammadi-Samani Soliman Mohammadi-Samani Polymers Blending as Release Modulating Tool in Drug Delivery Frontiers in Materials polymers blending core-shell polymeric carriers block copolymers physical mixtures release profile drug delivery |
| title | Polymers Blending as Release Modulating Tool in Drug Delivery |
| title_full | Polymers Blending as Release Modulating Tool in Drug Delivery |
| title_fullStr | Polymers Blending as Release Modulating Tool in Drug Delivery |
| title_full_unstemmed | Polymers Blending as Release Modulating Tool in Drug Delivery |
| title_short | Polymers Blending as Release Modulating Tool in Drug Delivery |
| title_sort | polymers blending as release modulating tool in drug delivery |
| topic | polymers blending core-shell polymeric carriers block copolymers physical mixtures release profile drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2021.752813/full |
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