Advanced glycation end products and cognitive impairment in schizophrenia.
Advanced glycation end products play a key role in the pathophysiology of schizophrenia. Cognitive impairment is one of the central features of schizophrenia; however, the association between advanced glycation end products and cognitive impairment remains unknown. This study investigated whether ad...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0251283 |
| _version_ | 1819034971588788224 |
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| author | Akiko Kobori Mitsuhiro Miyashita Yasuhiro Miyano Kazuhiro Suzuki Kazuya Toriumi Kazuhiro Niizato Kenichi Oshima Atsushi Imai Yukihiro Nagase Akane Yoshikawa Yasue Horiuchi Syudo Yamasaki Atsushi Nishida Satoshi Usami Shunya Takizawa Masanari Itokawa Heii Arai Makoto Arai |
| author_facet | Akiko Kobori Mitsuhiro Miyashita Yasuhiro Miyano Kazuhiro Suzuki Kazuya Toriumi Kazuhiro Niizato Kenichi Oshima Atsushi Imai Yukihiro Nagase Akane Yoshikawa Yasue Horiuchi Syudo Yamasaki Atsushi Nishida Satoshi Usami Shunya Takizawa Masanari Itokawa Heii Arai Makoto Arai |
| author_sort | Akiko Kobori |
| collection | DOAJ |
| description | Advanced glycation end products play a key role in the pathophysiology of schizophrenia. Cognitive impairment is one of the central features of schizophrenia; however, the association between advanced glycation end products and cognitive impairment remains unknown. This study investigated whether advanced glycation end products affect the cognitive domain in patients with schizophrenia. A total of 58 patients with chronic schizophrenia were included in this cross-sectional study. Plasma advanced glycation end products were measured using high-performance liquid chromatography (HPLC). Neuropsychological and cognitive functions were assessed using the Wechsler Adult Intelligence Scale, Third Version, and the Wisconsin Card Sorting Test Keio-FS version. Multiple regression analysis adjusted for age, sex, body mass index, educational years, daily dose of antipsychotics, and psychotic symptoms revealed that processing speed was significantly associated with plasma pentosidine, a representative advanced glycation end product (standardized β = -0.425; p = 0.009). Processing speed is the cognitive domain affected by advanced glycation end products. Considering preceding evidence that impaired processing speed is related to poor functional outcome, interventions targeted at reducing advanced glycation end products may contribute to promoting recovery of patients with schizophrenia as well as cognitive function improvement. |
| first_indexed | 2024-12-21T07:42:13Z |
| format | Article |
| id | doaj.art-d62960efdc3b42e6a2a0278374eba5d5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T07:42:13Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d62960efdc3b42e6a2a0278374eba5d52022-12-21T19:11:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01165e025128310.1371/journal.pone.0251283Advanced glycation end products and cognitive impairment in schizophrenia.Akiko KoboriMitsuhiro MiyashitaYasuhiro MiyanoKazuhiro SuzukiKazuya ToriumiKazuhiro NiizatoKenichi OshimaAtsushi ImaiYukihiro NagaseAkane YoshikawaYasue HoriuchiSyudo YamasakiAtsushi NishidaSatoshi UsamiShunya TakizawaMasanari ItokawaHeii AraiMakoto AraiAdvanced glycation end products play a key role in the pathophysiology of schizophrenia. Cognitive impairment is one of the central features of schizophrenia; however, the association between advanced glycation end products and cognitive impairment remains unknown. This study investigated whether advanced glycation end products affect the cognitive domain in patients with schizophrenia. A total of 58 patients with chronic schizophrenia were included in this cross-sectional study. Plasma advanced glycation end products were measured using high-performance liquid chromatography (HPLC). Neuropsychological and cognitive functions were assessed using the Wechsler Adult Intelligence Scale, Third Version, and the Wisconsin Card Sorting Test Keio-FS version. Multiple regression analysis adjusted for age, sex, body mass index, educational years, daily dose of antipsychotics, and psychotic symptoms revealed that processing speed was significantly associated with plasma pentosidine, a representative advanced glycation end product (standardized β = -0.425; p = 0.009). Processing speed is the cognitive domain affected by advanced glycation end products. Considering preceding evidence that impaired processing speed is related to poor functional outcome, interventions targeted at reducing advanced glycation end products may contribute to promoting recovery of patients with schizophrenia as well as cognitive function improvement.https://doi.org/10.1371/journal.pone.0251283 |
| spellingShingle | Akiko Kobori Mitsuhiro Miyashita Yasuhiro Miyano Kazuhiro Suzuki Kazuya Toriumi Kazuhiro Niizato Kenichi Oshima Atsushi Imai Yukihiro Nagase Akane Yoshikawa Yasue Horiuchi Syudo Yamasaki Atsushi Nishida Satoshi Usami Shunya Takizawa Masanari Itokawa Heii Arai Makoto Arai Advanced glycation end products and cognitive impairment in schizophrenia. PLoS ONE |
| title | Advanced glycation end products and cognitive impairment in schizophrenia. |
| title_full | Advanced glycation end products and cognitive impairment in schizophrenia. |
| title_fullStr | Advanced glycation end products and cognitive impairment in schizophrenia. |
| title_full_unstemmed | Advanced glycation end products and cognitive impairment in schizophrenia. |
| title_short | Advanced glycation end products and cognitive impairment in schizophrenia. |
| title_sort | advanced glycation end products and cognitive impairment in schizophrenia |
| url | https://doi.org/10.1371/journal.pone.0251283 |
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