The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner

The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner

Abstract Recombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the observed discordance in vector-mediated transdu...

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Bibliographic Details
Main Authors: Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Mark A. Kay
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38106-3

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