The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming
Abstract One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no protein-coding potential and mainly include microRNAs, lncRNAs and circRNAs. Accumula...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-03186-0 |
| _version_ | 1827377153470103552 |
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| author | Shizhen Li Mingjing Peng Shiming Tan Linda Oyang Jinguan Lin Longzheng Xia Jiewen Wang Nayiyuan Wu Xianjie Jiang Qiu Peng Yujuan Zhou Qianjin Liao |
| author_facet | Shizhen Li Mingjing Peng Shiming Tan Linda Oyang Jinguan Lin Longzheng Xia Jiewen Wang Nayiyuan Wu Xianjie Jiang Qiu Peng Yujuan Zhou Qianjin Liao |
| author_sort | Shizhen Li |
| collection | DOAJ |
| description | Abstract One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no protein-coding potential and mainly include microRNAs, lncRNAs and circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating cancer metabolic reprogramming, and the altered metabolic networks mediated by ncRNAs primarily drive carcinogenesis by regulating the expression of metabolic enzymes and transporter proteins. Importantly, accumulated research has revealed that dysregulated ncRNAs mediate metabolic reprogramming contributing to the generation of therapeutic tolerance. Elucidating the molecular mechanism of ncRNAs in cancer metabolic reprogramming can provide promising metabolism-related therapeutic targets for treatment as well as overcome therapeutic tolerance. In conclusion, this review updates the latest molecular mechanisms of ncRNAs related to cancer metabolic reprogramming. |
| first_indexed | 2024-03-08T12:34:49Z |
| format | Article |
| id | doaj.art-d62b46c70ce04d208a45cb8bc31a2341 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-08T12:34:49Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-d62b46c70ce04d208a45cb8bc31a23412024-01-21T12:36:18ZengBMCCancer Cell International1475-28672024-01-0124112010.1186/s12935-023-03186-0The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogrammingShizhen Li0Mingjing Peng1Shiming Tan2Linda Oyang3Jinguan Lin4Longzheng Xia5Jiewen Wang6Nayiyuan Wu7Xianjie Jiang8Qiu Peng9Yujuan Zhou10Qianjin Liao11Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityAbstract One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no protein-coding potential and mainly include microRNAs, lncRNAs and circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating cancer metabolic reprogramming, and the altered metabolic networks mediated by ncRNAs primarily drive carcinogenesis by regulating the expression of metabolic enzymes and transporter proteins. Importantly, accumulated research has revealed that dysregulated ncRNAs mediate metabolic reprogramming contributing to the generation of therapeutic tolerance. Elucidating the molecular mechanism of ncRNAs in cancer metabolic reprogramming can provide promising metabolism-related therapeutic targets for treatment as well as overcome therapeutic tolerance. In conclusion, this review updates the latest molecular mechanisms of ncRNAs related to cancer metabolic reprogramming.https://doi.org/10.1186/s12935-023-03186-0NcRNAsMetabolic reprogrammingCancer therapeutic tolerance |
| spellingShingle | Shizhen Li Mingjing Peng Shiming Tan Linda Oyang Jinguan Lin Longzheng Xia Jiewen Wang Nayiyuan Wu Xianjie Jiang Qiu Peng Yujuan Zhou Qianjin Liao The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming Cancer Cell International NcRNAs Metabolic reprogramming Cancer therapeutic tolerance |
| title | The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming |
| title_full | The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming |
| title_fullStr | The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming |
| title_full_unstemmed | The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming |
| title_short | The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming |
| title_sort | roles and molecular mechanisms of non coding rna in cancer metabolic reprogramming |
| topic | NcRNAs Metabolic reprogramming Cancer therapeutic tolerance |
| url | https://doi.org/10.1186/s12935-023-03186-0 |
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