Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study
ABSTRACT BACKGROUND: Since February 2020, data on the clinical features of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their clinical evolution have been gathered and intensively discussed, especially in countries with dramatic dissemination of this disease...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2020-11-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600490&tlng=en |
| _version_ | 1798021603807723520 |
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| author | Israel Júnior Borges do Nascimento Luiz Ricardo Pinto Valéria Alves Fernandes Israel Molina Romero João Antonio de Queiroz Oliveira Milena Soriano Marcolino Maria Fátima Leite |
| author_facet | Israel Júnior Borges do Nascimento Luiz Ricardo Pinto Valéria Alves Fernandes Israel Molina Romero João Antonio de Queiroz Oliveira Milena Soriano Marcolino Maria Fátima Leite |
| author_sort | Israel Júnior Borges do Nascimento |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Since February 2020, data on the clinical features of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their clinical evolution have been gathered and intensively discussed, especially in countries with dramatic dissemination of this disease. OBJECTIVE: To assess the clinical features of Brazilian patients with SARS-CoV-2 and analyze its local epidemiological features. DESIGN AND SETTING: Observational retrospective study conducted using data from an official electronic platform for recording confirmed SARS-CoV-2 cases. METHODS: We extracted data from patients based in the state of Pernambuco who were registered on the platform of the Center for Strategic Health Surveillance Information, between February 26 and May 25, 2020. Clinical signs/symptoms, case evolution over time, distribution of confirmed, recovered and fatal cases and relationship between age group and gender were assessed. RESULTS: We included 28,854 patients who were positive for SARS-CoV-2 (56.13% females), of median age 44.18 years. SARS-CoV-2 infection was most frequent among adults aged 30-39 years. Among cases that progressed to death, the most frequent age range was 70-79 years. Overall, the mortality rate in the cohort was 8.06%; recovery rate, 30.7%; and hospital admission rate (up to the end of follow-up), 17.3%. The average length of time between symptom onset and death was 10.3 days. The most commonly reported symptoms were coughing (42.39%), fever (38.03%) and dyspnea/respiratory distress with oxygen saturation < 95% (30.98%). CONCLUSION: Coughing, fever and dyspnea/respiratory distress with oxygen saturation < 95% were the commonest symptoms. The case-fatality rate was 8.06% and the hospitalization rate, 17.3%. |
| first_indexed | 2024-04-11T17:16:18Z |
| format | Article |
| id | doaj.art-d62c8c027cdc4bac997a9c82a2b0cbaf |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-04-11T17:16:18Z |
| publishDate | 2020-11-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-d62c8c027cdc4bac997a9c82a2b0cbaf2022-12-22T04:12:39ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602020-11-01138649049710.1590/1516-3180.2020.00365.r1.08092020Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective studyIsrael Júnior Borges do Nascimentohttps://orcid.org/0000-0001-5240-0493Luiz Ricardo Pintohttps://orcid.org/0000-0001-5082-9595Valéria Alves Fernandeshttps://orcid.org/0000-0003-1731-4738Israel Molina Romerohttps://orcid.org/0000-0001-6642-7515João Antonio de Queiroz Oliveirahttps://orcid.org/0000-0003-3116-4713Milena Soriano Marcolinohttps://orcid.org/0000-0003-4278-3771Maria Fátima Leitehttps://orcid.org/0000-0001-9709-8865ABSTRACT BACKGROUND: Since February 2020, data on the clinical features of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their clinical evolution have been gathered and intensively discussed, especially in countries with dramatic dissemination of this disease. OBJECTIVE: To assess the clinical features of Brazilian patients with SARS-CoV-2 and analyze its local epidemiological features. DESIGN AND SETTING: Observational retrospective study conducted using data from an official electronic platform for recording confirmed SARS-CoV-2 cases. METHODS: We extracted data from patients based in the state of Pernambuco who were registered on the platform of the Center for Strategic Health Surveillance Information, between February 26 and May 25, 2020. Clinical signs/symptoms, case evolution over time, distribution of confirmed, recovered and fatal cases and relationship between age group and gender were assessed. RESULTS: We included 28,854 patients who were positive for SARS-CoV-2 (56.13% females), of median age 44.18 years. SARS-CoV-2 infection was most frequent among adults aged 30-39 years. Among cases that progressed to death, the most frequent age range was 70-79 years. Overall, the mortality rate in the cohort was 8.06%; recovery rate, 30.7%; and hospital admission rate (up to the end of follow-up), 17.3%. The average length of time between symptom onset and death was 10.3 days. The most commonly reported symptoms were coughing (42.39%), fever (38.03%) and dyspnea/respiratory distress with oxygen saturation < 95% (30.98%). CONCLUSION: Coughing, fever and dyspnea/respiratory distress with oxygen saturation < 95% were the commonest symptoms. The case-fatality rate was 8.06% and the hospitalization rate, 17.3%.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600490&tlng=enSevere acute respiratory syndrome coronavirus 2 [supplementary concept]COVID-19 [supplementary concept]Coronavirus infectionsMandatory reportingPublic reporting of healthcare dataInfectious diseasesnCoV-2019Novel coronavirus2019-nCoV infections2019 novel coronavirus infection |
| spellingShingle | Israel Júnior Borges do Nascimento Luiz Ricardo Pinto Valéria Alves Fernandes Israel Molina Romero João Antonio de Queiroz Oliveira Milena Soriano Marcolino Maria Fátima Leite Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study São Paulo Medical Journal Severe acute respiratory syndrome coronavirus 2 [supplementary concept] COVID-19 [supplementary concept] Coronavirus infections Mandatory reporting Public reporting of healthcare data Infectious diseases nCoV-2019 Novel coronavirus 2019-nCoV infections 2019 novel coronavirus infection |
| title | Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study |
| title_full | Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study |
| title_fullStr | Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study |
| title_full_unstemmed | Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study |
| title_short | Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study |
| title_sort | clinical characteristics and outcomes among brazilian patients with severe acute respiratory syndrome coronavirus 2 infection an observational retrospective study |
| topic | Severe acute respiratory syndrome coronavirus 2 [supplementary concept] COVID-19 [supplementary concept] Coronavirus infections Mandatory reporting Public reporting of healthcare data Infectious diseases nCoV-2019 Novel coronavirus 2019-nCoV infections 2019 novel coronavirus infection |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600490&tlng=en |
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