PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h
Abstract Background [18F]PSMA-1007 is a prostate specific membrane antigen (PSMA) ligand for positron emission tomography (PET) imaging of prostate cancer. Current guidelines recommend imaging 90–120 min after injection but strong data about optimal timing is lacking. Our aim was to study whether im...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-05-01
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| Series: | European Journal of Hybrid Imaging |
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| Online Access: | https://doi.org/10.1186/s41824-023-00167-4 |
| _version_ | 1797832252346859520 |
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| author | Erland Hvittfeldt Ulrika Bitzén David Minarik Jenny Oddstig Berit Olsson Elin Trägårdh |
| author_facet | Erland Hvittfeldt Ulrika Bitzén David Minarik Jenny Oddstig Berit Olsson Elin Trägårdh |
| author_sort | Erland Hvittfeldt |
| collection | DOAJ |
| description | Abstract Background [18F]PSMA-1007 is a prostate specific membrane antigen (PSMA) ligand for positron emission tomography (PET) imaging of prostate cancer. Current guidelines recommend imaging 90–120 min after injection but strong data about optimal timing is lacking. Our aim was to study whether imaging after 1 h and 2 h leads to a different number of detected lesions, with a specific focus on lesions that might lead to a change in treatment. Methods 195 patients underwent PET with computed tomography imaging 1 and 2 h after injection of [18F]PSMA-1007. Three readers assessed the status of the prostate or prostate bed and suspected metastases. We analyzed the location and number of found metastases to determine N- and M-stage of patients. We also analyzed standardized uptake values (SUV) in lesions and in normal tissue. Results Significantly more pelvic lymph nodes and bone metastases were found and higher N- and M-stages were seen after 2 h. In twelve patients (6.1%) two or three readers agreed on a higher N- or M-stage after 2 h. Conversely, in two patients (1.0%), two readers agreed on a higher stage at 1 h. SUVs in suspected malignant lesions and in normal tissues were higher at 2 h, but lower in the blood pool and urinary bladder. Conclusions Imaging at 2 h after injection of [18F]PSMA-1007 leads to more suspected metastases found than after 1 h, with higher staging in some patients and possible effect on patient treatment. |
| first_indexed | 2024-04-09T14:05:56Z |
| format | Article |
| id | doaj.art-d62d42e809cf4c328fd925fa82c470ac |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-04-09T14:05:56Z |
| publishDate | 2023-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-d62d42e809cf4c328fd925fa82c470ac2023-05-07T11:03:25ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362023-05-017111010.1186/s41824-023-00167-4PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 hErland Hvittfeldt0Ulrika Bitzén1David Minarik2Jenny Oddstig3Berit Olsson4Elin Trägårdh5Department of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund UniversityDepartment of Clinical Physiology and Nuclear Medicine, Skåne University HospitalDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund UniversityDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund UniversityDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund UniversityDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund UniversityAbstract Background [18F]PSMA-1007 is a prostate specific membrane antigen (PSMA) ligand for positron emission tomography (PET) imaging of prostate cancer. Current guidelines recommend imaging 90–120 min after injection but strong data about optimal timing is lacking. Our aim was to study whether imaging after 1 h and 2 h leads to a different number of detected lesions, with a specific focus on lesions that might lead to a change in treatment. Methods 195 patients underwent PET with computed tomography imaging 1 and 2 h after injection of [18F]PSMA-1007. Three readers assessed the status of the prostate or prostate bed and suspected metastases. We analyzed the location and number of found metastases to determine N- and M-stage of patients. We also analyzed standardized uptake values (SUV) in lesions and in normal tissue. Results Significantly more pelvic lymph nodes and bone metastases were found and higher N- and M-stages were seen after 2 h. In twelve patients (6.1%) two or three readers agreed on a higher N- or M-stage after 2 h. Conversely, in two patients (1.0%), two readers agreed on a higher stage at 1 h. SUVs in suspected malignant lesions and in normal tissues were higher at 2 h, but lower in the blood pool and urinary bladder. Conclusions Imaging at 2 h after injection of [18F]PSMA-1007 leads to more suspected metastases found than after 1 h, with higher staging in some patients and possible effect on patient treatment.https://doi.org/10.1186/s41824-023-00167-4[18F]PSMA-1007Prostate cancerUptake timePET/CTPSMA |
| spellingShingle | Erland Hvittfeldt Ulrika Bitzén David Minarik Jenny Oddstig Berit Olsson Elin Trägårdh PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h European Journal of Hybrid Imaging [18F]PSMA-1007 Prostate cancer Uptake time PET/CT PSMA |
| title | PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h |
| title_full | PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h |
| title_fullStr | PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h |
| title_full_unstemmed | PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h |
| title_short | PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h |
| title_sort | pet ct imaging 2 h after injection of 18f psma 1007 can lead to higher staging of prostate cancer than imaging after 1 h |
| topic | [18F]PSMA-1007 Prostate cancer Uptake time PET/CT PSMA |
| url | https://doi.org/10.1186/s41824-023-00167-4 |
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