Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism
<i>Background:</i> Many and diverse autoimmune abnormalities have been reported in children with autism. Natural autoantibodies (NAAbs) play important immunoregulatory roles in recognition of the immune self. The objective of this study was to examine the presence of NAAbs in the sera of...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/715 |
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| author | Sylvie Tordjman Annaëlle Charrier Michel Kazatchkine Pierre Roubertoux Michel Botbol Guillaume Bronsard Stratis Avrameas |
| author_facet | Sylvie Tordjman Annaëlle Charrier Michel Kazatchkine Pierre Roubertoux Michel Botbol Guillaume Bronsard Stratis Avrameas |
| author_sort | Sylvie Tordjman |
| collection | DOAJ |
| description | <i>Background:</i> Many and diverse autoimmune abnormalities have been reported in children with autism. Natural autoantibodies (NAAbs) play important immunoregulatory roles in recognition of the immune self. The objective of this study was to examine the presence of NAAbs in the sera of children with autism and across severity subgroups of autistic behavioral impairments. <i>Methods:</i> NAAbs were titrated in sera through an ELISA procedure in 60 low-functioning children with autism and 112 typically developing controls matched for age, sex and puberty. <i>Results:</i> Serum titers of IgG anti-F(ab’)<sub>2</sub> autoantibodies were significantly lower in children with autism compared to typically developing controls (<i>p</i> < 0.0001), and were significantly negatively associated with autism severity (<i>p</i> = 0.0001). This data appears to be related more specifically to autism than to intellectual disability, given that IgG anti-F(ab’)<sub>2</sub> levels were significantly negatively correlated with IQ scores in the autism group (<i>p</i> = 0.01). <i>Conclusions:</i> This is the first report in autism of abnormally low natural anti-F(ab’)<sub>2</sub> autoantibody activity. The findings suggest a dysfunction of self-recognition mechanisms which may play a role in the pathogenesis of autism, especially for the severely affected children. These findings strengthen the hypothesis of an autoimmune process in autism and open the prospect of alternative medical treatment. Further neuroimmunological research is warranted to understand the exact mechanisms underlying this reduced natural IgG anti-F (ab’)<sub>2</sub> autoantibody activity, and to assess its impact on the pathophysiology and behavioral expression of autism. |
| first_indexed | 2024-03-11T06:54:56Z |
| format | Article |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:54:56Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d62e3225675d4442b9a5eaa6a20a2a9c2023-11-17T09:44:33ZengMDPI AGBiomedicines2227-90592023-02-0111371510.3390/biomedicines11030715Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with AutismSylvie Tordjman0Annaëlle Charrier1Michel Kazatchkine2Pierre Roubertoux3Michel Botbol4Guillaume Bronsard5Stratis Avrameas6Integrative Neuroscience and Cognition Center (INCC), 75006 Paris, FrancePôle Hospitalo-Universitaire de Psychiatrie de l’Enfant et de l’Adolescent de Rennes (PHUPEA), Centre Hospitalier Guillaume Régnier (CHGR) et Université de Rennes 1, 35000 Rennes, FranceINSERM Unité 430, Immunopathologie Humaine, 75014 Paris, FranceInstitut de Neurosciences Physiologiques et Cognitives, INPC.CNRS, 13256 Marseille, FranceSchool of Medicine, Université de Bretagne Occidentale (UBO), 29238 Brest, FranceService Hospitalo-Universitaire de Psychiatrie de l’Enfant et de l’Adolescent de Brest, UBO et CHU de Brest, 29238 Brest, FranceLaboratory of Immunology, Pasteur Institute, 75015 Paris, France<i>Background:</i> Many and diverse autoimmune abnormalities have been reported in children with autism. Natural autoantibodies (NAAbs) play important immunoregulatory roles in recognition of the immune self. The objective of this study was to examine the presence of NAAbs in the sera of children with autism and across severity subgroups of autistic behavioral impairments. <i>Methods:</i> NAAbs were titrated in sera through an ELISA procedure in 60 low-functioning children with autism and 112 typically developing controls matched for age, sex and puberty. <i>Results:</i> Serum titers of IgG anti-F(ab’)<sub>2</sub> autoantibodies were significantly lower in children with autism compared to typically developing controls (<i>p</i> < 0.0001), and were significantly negatively associated with autism severity (<i>p</i> = 0.0001). This data appears to be related more specifically to autism than to intellectual disability, given that IgG anti-F(ab’)<sub>2</sub> levels were significantly negatively correlated with IQ scores in the autism group (<i>p</i> = 0.01). <i>Conclusions:</i> This is the first report in autism of abnormally low natural anti-F(ab’)<sub>2</sub> autoantibody activity. The findings suggest a dysfunction of self-recognition mechanisms which may play a role in the pathogenesis of autism, especially for the severely affected children. These findings strengthen the hypothesis of an autoimmune process in autism and open the prospect of alternative medical treatment. Further neuroimmunological research is warranted to understand the exact mechanisms underlying this reduced natural IgG anti-F (ab’)<sub>2</sub> autoantibody activity, and to assess its impact on the pathophysiology and behavioral expression of autism.https://www.mdpi.com/2227-9059/11/3/715autoimmune processnatural autoantibodiesIgG anti-F (ab’)<sub>2</sub> autoantibodiesself-recognitionautism spectrum disorder |
| spellingShingle | Sylvie Tordjman Annaëlle Charrier Michel Kazatchkine Pierre Roubertoux Michel Botbol Guillaume Bronsard Stratis Avrameas Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism Biomedicines autoimmune process natural autoantibodies IgG anti-F (ab’)<sub>2</sub> autoantibodies self-recognition autism spectrum disorder |
| title | Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism |
| title_full | Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism |
| title_fullStr | Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism |
| title_full_unstemmed | Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism |
| title_short | Natural IgG Anti-F (ab’)<sub>2</sub> Autoantibody Activity in Children with Autism |
| title_sort | natural igg anti f ab sub 2 sub autoantibody activity in children with autism |
| topic | autoimmune process natural autoantibodies IgG anti-F (ab’)<sub>2</sub> autoantibodies self-recognition autism spectrum disorder |
| url | https://www.mdpi.com/2227-9059/11/3/715 |
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