Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence?
The aim of the study was to answer the questions whether a chronic disease can have a significant impact on the level of adherence and whether there are differences in adherence-related predictors depending on the chronic disease. The study included 1,571 patients (mean age 64.7 ± 11.3) with chronic...
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Frontiers Media S.A.
2020-08-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.01157/full |
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author | Beata Jankowska-Polańska Piotr Karniej Jacek Polański Mariola Seń Natalia Świątoniowska-Lonc Elżbieta Grochans |
author_facet | Beata Jankowska-Polańska Piotr Karniej Jacek Polański Mariola Seń Natalia Świątoniowska-Lonc Elżbieta Grochans |
author_sort | Beata Jankowska-Polańska |
collection | DOAJ |
description | The aim of the study was to answer the questions whether a chronic disease can have a significant impact on the level of adherence and whether there are differences in adherence-related predictors depending on the chronic disease. The study included 1,571 patients (mean age 64.7 ± 11.3) with chronic diseases [1,030 diabetes mellitus (DM) type 2 and 541 hypertension (HA)]. Adherence was assessed using the Adherence Refills Medication Scale (ARMS). The average adherence score for the whole group was 18.9. Fifty-five percent of patients had a low level of adherence. A comparison between DM and HA shows a statistically significant difference and a higher level of adherence with pharmacological recommendations in the group of patients with type 2 DM (17.5 ± 12.0 vs 19.2 ± 8.0). In the single factors analysis, HA diagnosis had a statistically significant negative effect on adherence (β=0.92, p ≤ 0.001). In simple linear regression analysis, independent of chronic disease, a higher level of adherence was observed among women (β=−0.40, p=0.015), people with secondary education (β=−1.26, p ≤ 0.001), and inactive patients (β=−0.48; p=0.005). However, place of residence - countryside (β =0.35, p=0.044) and higher education (β=0.90, p ≤ 0.001) had a negative influence on the level of adherence. In multiple linear regression analysis HA (B=0.99; p ≤ 0.001), female gender (B=−0.47; p=0.003) and secondary education (B=−1.16; p ≤ 0.001) were important independent determinants of adherence. (1) Hypertension is an independent, statistically significant predictor that reduces the adherence level. (2) Female gender and higher education are the most important determinants improving adherence to pharmacological therapy. (3) There is a different pattern of predictors of adherence among patients: occupational activity plays an important role in DM, while education plays a role in HA. |
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language | English |
last_indexed | 2024-12-14T15:08:17Z |
publishDate | 2020-08-01 |
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spelling | doaj.art-d6301de644d842e0ab3867017d0940512022-12-21T22:56:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-08-011110.3389/fphar.2020.01157534025Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence?Beata Jankowska-Polańska0Piotr Karniej1Jacek Polański2Mariola Seń3Natalia Świątoniowska-Lonc4Elżbieta Grochans5Department of Clinical Nursing, Public Health Department, Wroclaw Medical University, Wrocław, PolandDepartment of Health Promotion, Public Health Department, Wroclaw Medical University, Wrocław, PolandDepartment of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wrocław, PolandDepartment of Health Promotion, Public Health Department, Wroclaw Medical University, Wrocław, PolandDepartment of Clinical Nursing, Public Health Department, Wroclaw Medical University, Wrocław, PolandDepartment of Nursing, Pomeranian Medical University in Szczecin, Szczecin, PolandThe aim of the study was to answer the questions whether a chronic disease can have a significant impact on the level of adherence and whether there are differences in adherence-related predictors depending on the chronic disease. The study included 1,571 patients (mean age 64.7 ± 11.3) with chronic diseases [1,030 diabetes mellitus (DM) type 2 and 541 hypertension (HA)]. Adherence was assessed using the Adherence Refills Medication Scale (ARMS). The average adherence score for the whole group was 18.9. Fifty-five percent of patients had a low level of adherence. A comparison between DM and HA shows a statistically significant difference and a higher level of adherence with pharmacological recommendations in the group of patients with type 2 DM (17.5 ± 12.0 vs 19.2 ± 8.0). In the single factors analysis, HA diagnosis had a statistically significant negative effect on adherence (β=0.92, p ≤ 0.001). In simple linear regression analysis, independent of chronic disease, a higher level of adherence was observed among women (β=−0.40, p=0.015), people with secondary education (β=−1.26, p ≤ 0.001), and inactive patients (β=−0.48; p=0.005). However, place of residence - countryside (β =0.35, p=0.044) and higher education (β=0.90, p ≤ 0.001) had a negative influence on the level of adherence. In multiple linear regression analysis HA (B=0.99; p ≤ 0.001), female gender (B=−0.47; p=0.003) and secondary education (B=−1.16; p ≤ 0.001) were important independent determinants of adherence. (1) Hypertension is an independent, statistically significant predictor that reduces the adherence level. (2) Female gender and higher education are the most important determinants improving adherence to pharmacological therapy. (3) There is a different pattern of predictors of adherence among patients: occupational activity plays an important role in DM, while education plays a role in HA.https://www.frontiersin.org/article/10.3389/fphar.2020.01157/fulladherencehypertensive treatmenthypertensiondiabetesfactors |
spellingShingle | Beata Jankowska-Polańska Piotr Karniej Jacek Polański Mariola Seń Natalia Świątoniowska-Lonc Elżbieta Grochans Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence? Frontiers in Pharmacology adherence hypertensive treatment hypertension diabetes factors |
title | Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence? |
title_full | Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence? |
title_fullStr | Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence? |
title_full_unstemmed | Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence? |
title_short | Diabetes Mellitus Versus Hypertension—Does Disease Affect Pharmacological Adherence? |
title_sort | diabetes mellitus versus hypertension does disease affect pharmacological adherence |
topic | adherence hypertensive treatment hypertension diabetes factors |
url | https://www.frontiersin.org/article/10.3389/fphar.2020.01157/full |
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