Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on da...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Proteomes |
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| Online Access: | https://www.mdpi.com/2227-7382/11/3/22 |
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| author | Eduardo Alvarez-Rivera Emanuel J. Ortiz-Hernández Elyette Lugo Lorraine M. Lozada-Reyes Nawal M. Boukli |
| author_facet | Eduardo Alvarez-Rivera Emanuel J. Ortiz-Hernández Elyette Lugo Lorraine M. Lozada-Reyes Nawal M. Boukli |
| author_sort | Eduardo Alvarez-Rivera |
| collection | DOAJ |
| description | Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on data mining are becoming increasingly powerful for identifying both potential disease mechanisms as well as indicators for disease progression and overall survival predictive and prognostic molecular markers for cancer. Furthermore, mass spectrometry (MS) integrations satisfy the ongoing demand for in-depth biomarker validation. For the purpose of this review, we will highlight the current developments based on MS sensitivity, to place quantitative proteomics into clinical settings and provide a perspective to integrate proteomics data for future applications in cancer precision medicine. We will also discuss malignancies associated with oncogenic viruses such as Acquire Immunodeficiency Syndrome (AIDS) and suggest novel mechanisms behind this phenomenon. Human Immunodeficiency Virus type-1 (HIV-1) proteins are known to be oncogenic per se, to induce oxidative and endoplasmic reticulum stresses, and to be released from the infected or expressing cells. HIV-1 proteins can act alone or in collaboration with other known oncoproteins, which cause the bulk of malignancies in people living with HIV-1 on ART. |
| first_indexed | 2024-03-10T22:08:49Z |
| format | Article |
| id | doaj.art-d63040886d464e1e80b67d96d982ae2e |
| institution | Directory Open Access Journal |
| issn | 2227-7382 |
| language | English |
| last_indexed | 2024-03-10T22:08:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proteomes |
| spelling | doaj.art-d63040886d464e1e80b67d96d982ae2e2023-11-19T12:43:16ZengMDPI AGProteomes2227-73822023-07-011132210.3390/proteomes11030022Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy MechanismsEduardo Alvarez-Rivera0Emanuel J. Ortiz-Hernández1Elyette Lugo2Lorraine M. Lozada-Reyes3Nawal M. Boukli4Biomedical Proteomics Facility, Department of Microbiology and Immunology, Universidad Central del Caribe, School of Medicine, Bayamón, PR 00960, USABiomedical Proteomics Facility, Department of Microbiology and Immunology, Universidad Central del Caribe, School of Medicine, Bayamón, PR 00960, USABiomedical Proteomics Facility, Department of Microbiology and Immunology, Universidad Central del Caribe, School of Medicine, Bayamón, PR 00960, USADepartment of Biology, Universidad de Puerto Rico, Bayamón, PR 00960, USABiomedical Proteomics Facility, Department of Microbiology and Immunology, Universidad Central del Caribe, School of Medicine, Bayamón, PR 00960, USARecent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on data mining are becoming increasingly powerful for identifying both potential disease mechanisms as well as indicators for disease progression and overall survival predictive and prognostic molecular markers for cancer. Furthermore, mass spectrometry (MS) integrations satisfy the ongoing demand for in-depth biomarker validation. For the purpose of this review, we will highlight the current developments based on MS sensitivity, to place quantitative proteomics into clinical settings and provide a perspective to integrate proteomics data for future applications in cancer precision medicine. We will also discuss malignancies associated with oncogenic viruses such as Acquire Immunodeficiency Syndrome (AIDS) and suggest novel mechanisms behind this phenomenon. Human Immunodeficiency Virus type-1 (HIV-1) proteins are known to be oncogenic per se, to induce oxidative and endoplasmic reticulum stresses, and to be released from the infected or expressing cells. HIV-1 proteins can act alone or in collaboration with other known oncoproteins, which cause the bulk of malignancies in people living with HIV-1 on ART.https://www.mdpi.com/2227-7382/11/3/22quantitative proteomicsmass spectrometrybiomarkerscancerco-morbidityHIV-associated malignancies |
| spellingShingle | Eduardo Alvarez-Rivera Emanuel J. Ortiz-Hernández Elyette Lugo Lorraine M. Lozada-Reyes Nawal M. Boukli Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms Proteomes quantitative proteomics mass spectrometry biomarkers cancer co-morbidity HIV-associated malignancies |
| title | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
| title_full | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
| title_fullStr | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
| title_full_unstemmed | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
| title_short | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
| title_sort | oncogenic proteomics approaches for translational research and hiv associated malignancy mechanisms |
| topic | quantitative proteomics mass spectrometry biomarkers cancer co-morbidity HIV-associated malignancies |
| url | https://www.mdpi.com/2227-7382/11/3/22 |
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