Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study
Individuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive Enhancement Therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample of outpatients with schizophrenia and alcohol and/or cannabis substance use...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00186/full |
| _version_ | 1819087539090227200 |
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| author | Jessica Ann Wojtalik Susan S Hogarty Jack R Cornelius Mary L Phillips Matcheri S Keshavan Christina E Newhill Shaun M Eack Shaun M Eack |
| author_facet | Jessica Ann Wojtalik Susan S Hogarty Jack R Cornelius Mary L Phillips Matcheri S Keshavan Christina E Newhill Shaun M Eack Shaun M Eack |
| author_sort | Jessica Ann Wojtalik |
| collection | DOAJ |
| description | Individuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive Enhancement Therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample of outpatients with schizophrenia and alcohol and/or cannabis substance use problems participating in an 18-month randomized trial of CET (n = 10) or usual care (n = 4) completed post-treatment functional neuroimaging using an emotion regulation task. General linear models explored CET effects on brain activity in emotional neurocircuitry. Individuals treated with CET had significantly greater activation in broad regions of the prefrontal cortex, limbic and striatal systems implicated in emotion regulation compared to usual care. Differential activation favoring CET in prefrontal regions and the insula mediated behavioral improvements in emotional processing. Our data lend preliminary support of CET effects on neuroplasticity in fronto-limbic and striatal circuitries which mediate emotion regulation in people with schizophrenia and comorbid substance misuse problems. |
| first_indexed | 2024-12-21T21:37:45Z |
| format | Article |
| id | doaj.art-d631544043054b1a8a4715de97d17fda |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T21:37:45Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d631544043054b1a8a4715de97d17fda2022-12-21T18:49:27ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402016-01-01610.3389/fpsyt.2015.00186173568Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary studyJessica Ann Wojtalik0Susan S Hogarty1Jack R Cornelius2Mary L Phillips3Matcheri S Keshavan4Christina E Newhill5Shaun M Eack6Shaun M Eack7University of PittsburghUniversity of Pittsburgh School of MedicineUniversity of Pittsburgh School of MedicineUniversity of Pittsburgh School of MedicineHarvard Medical SchoolUniversity of PittsburghUniversity of PittsburghUniversity of Pittsburgh School of MedicineIndividuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive Enhancement Therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample of outpatients with schizophrenia and alcohol and/or cannabis substance use problems participating in an 18-month randomized trial of CET (n = 10) or usual care (n = 4) completed post-treatment functional neuroimaging using an emotion regulation task. General linear models explored CET effects on brain activity in emotional neurocircuitry. Individuals treated with CET had significantly greater activation in broad regions of the prefrontal cortex, limbic and striatal systems implicated in emotion regulation compared to usual care. Differential activation favoring CET in prefrontal regions and the insula mediated behavioral improvements in emotional processing. Our data lend preliminary support of CET effects on neuroplasticity in fronto-limbic and striatal circuitries which mediate emotion regulation in people with schizophrenia and comorbid substance misuse problems.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00186/fullBrainSchizophreniaEmotion Regulationsubstance misuseCognitive Enhancement Therapy |
| spellingShingle | Jessica Ann Wojtalik Susan S Hogarty Jack R Cornelius Mary L Phillips Matcheri S Keshavan Christina E Newhill Shaun M Eack Shaun M Eack Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study Frontiers in Psychiatry Brain Schizophrenia Emotion Regulation substance misuse Cognitive Enhancement Therapy |
| title | Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study |
| title_full | Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study |
| title_fullStr | Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study |
| title_full_unstemmed | Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study |
| title_short | Cognitive enhancement therapy improves fronto-limbic regulation of emotion in alcohol and/or cannabis misusing schizophrenia: a preliminary study |
| title_sort | cognitive enhancement therapy improves fronto limbic regulation of emotion in alcohol and or cannabis misusing schizophrenia a preliminary study |
| topic | Brain Schizophrenia Emotion Regulation substance misuse Cognitive Enhancement Therapy |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00186/full |
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