Inhibition of JAK1,2 Prevents Fibrotic Remodeling of Pulmonary Vascular Bed and Improves Outcomes in the Rat Model of Chronic Thromboembolic Pulmonary Hypertension

Inhibition of JAK1,2 Prevents Fibrotic Remodeling of Pulmonary Vascular Bed and Improves Outcomes in the Rat Model of Chronic Thromboembolic Pulmonary Hypertension

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism with poor clinical outcomes. Therapeutic approaches to prevention of fibrotic remodeling of the pulmonary vascular bed in CTEPH are limited. In this work, we tested the hypothesis that Janus kina...

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Bibliographic Details
Main Authors: Andrei A. Karpov, Aleksandra M. Mihailova, Leonid A. Shilenko, Dariya D. Vaulina, Elizaveta E. Sidorova, Anna A. Akhmetova, Pavel M. Docshin, Alexander S. Krasichkov, Kseniia E. Sanarova, Olga M. Moiseeva, Michael M. Galagudza
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
JAK-STAT pathway
ruxolitinib
chronic thromboembolic pulmonary hypertension (CTEPH)
rodent model
microspheres
Online Access:https://www.mdpi.com/1422-0067/23/24/15646

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