Circular RNA: metabolism, functions and interactions with proteins
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biologica...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-020-01286-3 |
| _version_ | 1831540343228596224 |
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| author | Wei-Yi Zhou Ze-Rong Cai Jia Liu De-Shen Wang Huai-Qiang Ju Rui-Hua Xu |
| author_facet | Wei-Yi Zhou Ze-Rong Cai Jia Liu De-Shen Wang Huai-Qiang Ju Rui-Hua Xu |
| author_sort | Wei-Yi Zhou |
| collection | DOAJ |
| description | Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has revealed that a group of circRNAs can serve as protein decoys, scaffolds and recruiters. However, the existing research on circRNA-protein interactions is quite limited. Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions between proteins, tethering or sequestering proteins, recruiting proteins to chromatin, forming circRNA-protein-mRNA ternary complexes and translocating or redistributing proteins. Many discoveries have revealed that circRNAs have unique expression signatures and play crucial roles in a variety of diseases, enabling them to potentially act as diagnostic biomarkers and therapeutic targets. This review systematically evaluates the roles and mechanisms of circRNAs, with the hope of advancing translational medicine involving circRNAs. |
| first_indexed | 2024-12-16T23:57:13Z |
| format | Article |
| id | doaj.art-d632b21718e94b679d98a2fde221e564 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-16T23:57:13Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-d632b21718e94b679d98a2fde221e5642022-12-21T22:11:10ZengBMCMolecular Cancer1476-45982020-12-0119111910.1186/s12943-020-01286-3Circular RNA: metabolism, functions and interactions with proteinsWei-Yi Zhou0Ze-Rong Cai1Jia Liu2De-Shen Wang3Huai-Qiang Ju4Rui-Hua Xu5State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterAbstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has revealed that a group of circRNAs can serve as protein decoys, scaffolds and recruiters. However, the existing research on circRNA-protein interactions is quite limited. Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions between proteins, tethering or sequestering proteins, recruiting proteins to chromatin, forming circRNA-protein-mRNA ternary complexes and translocating or redistributing proteins. Many discoveries have revealed that circRNAs have unique expression signatures and play crucial roles in a variety of diseases, enabling them to potentially act as diagnostic biomarkers and therapeutic targets. This review systematically evaluates the roles and mechanisms of circRNAs, with the hope of advancing translational medicine involving circRNAs.https://doi.org/10.1186/s12943-020-01286-3CircRNACircRNA-protein interactionMechanismMetabolismFunction |
| spellingShingle | Wei-Yi Zhou Ze-Rong Cai Jia Liu De-Shen Wang Huai-Qiang Ju Rui-Hua Xu Circular RNA: metabolism, functions and interactions with proteins Molecular Cancer CircRNA CircRNA-protein interaction Mechanism Metabolism Function |
| title | Circular RNA: metabolism, functions and interactions with proteins |
| title_full | Circular RNA: metabolism, functions and interactions with proteins |
| title_fullStr | Circular RNA: metabolism, functions and interactions with proteins |
| title_full_unstemmed | Circular RNA: metabolism, functions and interactions with proteins |
| title_short | Circular RNA: metabolism, functions and interactions with proteins |
| title_sort | circular rna metabolism functions and interactions with proteins |
| topic | CircRNA CircRNA-protein interaction Mechanism Metabolism Function |
| url | https://doi.org/10.1186/s12943-020-01286-3 |
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