Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling

Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling

Osteoarthritis (OA) is a deteriorating disease of cartilage tissues mainly characterized as low-grade inflammation of the joint. Innate immune molecule surfactant protein D (SP-D) is a member of collectin family of collagenous Ca2+-dependent defense lectins and plays a vital role in the inflammatory...

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Bibliographic Details
Main Authors: Huanyu Jiang, Yubiao Zhang, Geliang Hu, Xiaobin Shang, Jianghua Ming, Ming Deng, Yaming Li, Yonggang Ma, Shiqing Liu, Yan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
surfactant protein D
osteoarthritis
inflammation
innate immunity
chondrocyte
toll-like receptor 4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.913901/full

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