ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM
Objective: To evaluate the effect of estrogen on wistar’s vaginal epithelium. Material & method: We divided 30 female wistars into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars as control. The second...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IKATAN AHLI UROLOGI INDONESIA
2016-11-01
|
| Series: | Jurnal Urologi Indonesia |
| Subjects: | |
| Online Access: | http://juri.urologi.or.id/juri/article/view/349 |
| _version_ | 1811244107154063360 |
|---|---|
| author | Abu Surur Suwandi Sugandi Zulhardi Haroen Bambang S Noegroho Tjahdjojati Tjahjodjati Ferry Safriadi Safendra Siregar Ricky Adriansjah Kuncoro Adi Betthy S Hernowo |
| author_facet | Abu Surur Suwandi Sugandi Zulhardi Haroen Bambang S Noegroho Tjahdjojati Tjahjodjati Ferry Safriadi Safendra Siregar Ricky Adriansjah Kuncoro Adi Betthy S Hernowo |
| author_sort | Abu Surur |
| collection | DOAJ |
| description | Objective: To evaluate the effect of estrogen on wistar’s vaginal epithelium. Material & method: We divided 30 female wistars into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars as control. The second group received estradiol 1 mg/kg/day, directly after ovariectomy. After 4 weeks the vagina was then harvested and stained with hematoxylin-eosin to evaluate the thickness of epithelial layer of vagina. A pair T-test was use for statistical analysis. Results: Estrogen ablation decreased the thickness of epithelial layer in wistar’s vagina. The mean thickness of epithelial layer in vagina were 3, 5, and 10 for each group respectively. The mean epithelial layer of the first group as well as the second group showed significant difference compared to control group (p>0,05), while the first group showed insignificant difference compared to the second group. Conclusion: Estrogen ablation seems to decrease the thickness of vaginal epithelium, while estrogen replacement revealed insignificant effect. |
| first_indexed | 2024-04-12T14:20:09Z |
| format | Article |
| id | doaj.art-d63891a8939e41e28364f66da8f685be |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-04-12T14:20:09Z |
| publishDate | 2016-11-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-d63891a8939e41e28364f66da8f685be2022-12-22T03:29:37ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022016-11-0117210.32421/juri.v17i2.349349ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUMAbu Surur0Suwandi Sugandi1Zulhardi Haroen2Bambang S Noegroho3Tjahdjojati Tjahjodjati4Ferry Safriadi5Safendra Siregar6Ricky Adriansjah7Kuncoro Adi8Betthy S Hernowo9Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Urology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung.Department of Anatomical Pathology, Padjadjaran University, Faculty of Medicine/Hasan Sadikin Hospital, Bandung.Objective: To evaluate the effect of estrogen on wistar’s vaginal epithelium. Material & method: We divided 30 female wistars into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars as control. The second group received estradiol 1 mg/kg/day, directly after ovariectomy. After 4 weeks the vagina was then harvested and stained with hematoxylin-eosin to evaluate the thickness of epithelial layer of vagina. A pair T-test was use for statistical analysis. Results: Estrogen ablation decreased the thickness of epithelial layer in wistar’s vagina. The mean thickness of epithelial layer in vagina were 3, 5, and 10 for each group respectively. The mean epithelial layer of the first group as well as the second group showed significant difference compared to control group (p>0,05), while the first group showed insignificant difference compared to the second group. Conclusion: Estrogen ablation seems to decrease the thickness of vaginal epithelium, while estrogen replacement revealed insignificant effect.http://juri.urologi.or.id/juri/article/view/349Estrogenvaginal epitheliumepithelial layerestrogen replacement therapylower urinary tract symptoms |
| spellingShingle | Abu Surur Suwandi Sugandi Zulhardi Haroen Bambang S Noegroho Tjahdjojati Tjahjodjati Ferry Safriadi Safendra Siregar Ricky Adriansjah Kuncoro Adi Betthy S Hernowo ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM Jurnal Urologi Indonesia Estrogen vaginal epithelium epithelial layer estrogen replacement therapy lower urinary tract symptoms |
| title | ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM |
| title_full | ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM |
| title_fullStr | ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM |
| title_full_unstemmed | ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM |
| title_short | ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM |
| title_sort | estrogen effect on wistar s vaginal epithelium |
| topic | Estrogen vaginal epithelium epithelial layer estrogen replacement therapy lower urinary tract symptoms |
| url | http://juri.urologi.or.id/juri/article/view/349 |
| work_keys_str_mv | AT abusurur estrogeneffectonwistarsvaginalepithelium AT suwandisugandi estrogeneffectonwistarsvaginalepithelium AT zulhardiharoen estrogeneffectonwistarsvaginalepithelium AT bambangsnoegroho estrogeneffectonwistarsvaginalepithelium AT tjahdjojatitjahjodjati estrogeneffectonwistarsvaginalepithelium AT ferrysafriadi estrogeneffectonwistarsvaginalepithelium AT safendrasiregar estrogeneffectonwistarsvaginalepithelium AT rickyadriansjah estrogeneffectonwistarsvaginalepithelium AT kuncoroadi estrogeneffectonwistarsvaginalepithelium AT betthyshernowo estrogeneffectonwistarsvaginalepithelium |